"[Researchers] investigated whether fetal neurons transplanted into a part of the mouse brain that does not normally produce new neurons of its own could repair an abnormal neural circuit. The recipients of the transplant treatment were genetically altered mice lacking the receptor for leptin, a hormone that regulates metabolism and body weight. In normal mice, leptin acts on neurons in a part of the brain called the hypothalamus, which regulates metabolism and other essential functions. But in the mutant mice, these neurons can't respond to leptin, and the mice become obese and diabetic. To see whether they could correct this defect, the researchers transplanted immature neurons taken from the hypothalami of fetal mice that had the normal leptin receptor gene into the same brain region of the obesity-prone mice.Using electrodes to record the electrical activity of hypothalamic neurons, the researchers confirmed that the transplanted cells responded to leptin as expected and could communicate with the recipient mouse's own neurons. 'These newly incorporated neurons were in a sense acting as antennas for leptin and sending those signals into the brain.'"
5TH ANNUAL RALLY WILL BE HELD SEPT 22TH, 2012
5th ANNUAL RALLY FOR ALI
IN SEARCH OF A CURE FOR DIABETES
ALL DONATIONS WILL GO TO HARVARD STEM CELL INSTITUTE
PICNIC FOR A CAUSE
KRAUSE’S GROVE, 2 Beach Road, Halfmoon, NY
SATURDAY, SEPTEMBER 21, 2013
1:00 PM TO 6:00 PM ~ RAIN OR SHINE
$30.00 per adult ticket at gate - $20.00 for children under 12
includes donation to Harvard Stem Cell Institute.
5 hour picnic with soda, beer, games, raffles, 50/50, live music
JAMBONE - THE BEAR BONES PROJECT - BLUE HAND LUKE
SPECIAL GUEST APPEARANCE BY AWARD-WINNING IRISH STEP DANCER
GRACE CATHERINE MOMROW (Ali’s cousin)
Abundant food and dessert being served 1:00 p.m. to 5:00 p.m.
Those who wish to join a pre-picnic motorcycle cavalcade around the beautiful Tomhannock Reservoir in Ali’s honor will meet at the Troy Plaza on Hoosick Street at 10:00 A.M. for sign up and the cavalcade will kick off at 11:00 A.M. sharp.
For more info: https://www.facebook.com/Rally4Ali
For Further Information
For the Run, Wally Urzan
For the Picnic & Cause
Monday, November 28, 2011
Saturday, November 19, 2011
John L. Brooks, 3d
Diabetes is now a global pandemic, afflicting 346 million people worldwide, and Massachusetts is squarely in the forefront of this unforgiving disease:
• About 407,000 adults are diagnosed with diabetes and another estimated 114,000 adults lhave type 2 diabetes, but do not know it.
• From 2005 through 2008, diabetes was the ninth leading cause of death in the Commonwealth.
• In 2009, nearly 5 percent of Massachusetts adults reported they had been diagnosed with pre-diabetes, which is blood glucose levels that are higher than normal but not high enough to be diagnosed as diabetes.
• The cost of diabetes in Massachusetts is $4.3 billion annually.
• Since 1999, there has been a 61 percent increase in the number of people diagnosed with diabetes in Massachusetts, a trend that will continue unless we all work together to change things.
Type 1 diabetes is predominantly initiated by family genetic factors. Type 2 diabetes, is accelerated by obesity, lack of exercise, lack of awareness, and a healthcare system that historically has focused on paying for downstream complications rather than prevention and proactive encouragement of healthy diets, exercise, medication adherence, and behavioral health issues.
As the United States faces the prospect of the incidence of diabetes rising from one in 10 citizens today, to one in three in the next 40 years, a new national commitment to address this disease head-on is essential.
At the Joslin Diabetes Center, we are catalyzing this call to action with the goal of a world free of type 1 and type 2 diabetes and their complications. We are reaching out across the Commonwealth to engage organizations, community centers, schools of public health and many others, to bring resources and energy to providing culturally tailored educational programs, tools, team-based resources and impactful care plans to inform and motivate families and their health teams to work collectively to reverse or slow this relentless diabetes tidal wave.
On November 19 our community of doctors, patients, families, friends and advocates will gather for Joslin’s annual High Hopes Gala and World Diabetes Day Celebration, our most important night of the year. This event supports innovation and research aimed at creating a world free of diabetes and its complications.
We must build partnerships and cost-effective, risk-sharing collaborations with other healthcare providers, payers, and federal, state and city agencies to share and leverage our expertise in novel and measurable ways. This is what is needed to help patients, families, primary care doctors and other healthcare providers and payers to tackle this disease and its dreaded complications. We must make this a priority. Our lives -- and the lives of our loved ones -- depend on it.
John L. Brooks 3d is president and CEO of the Joslin Diabetes Center.
Monday, November 14, 2011
World’s first stem cell bandage in human clinical trials
The company, which has received approval from the Medicines and Healthcare products Regulatory Agency (MHRA) for the world's first clinical trial using its Cell Bandage product, is funded by existing investors IP Group plc, the developer of intellectual property based businesses — and Oxford Technology Management as well as new investors including lead funder, Mr Osmond.
Azellon’s Cell Bandage has been designed as an alternative to the current treatment of surgical removal of the meniscus (meniscectomy), a procedure that more than 1.7 million people around the world per year are estimated to undergo. This common orthopaedic procedure often results in the early onset of osteoarthritis, leading to further joint surgery including total knee replacement.
The Cell Bandage, which in vitro (tissue culture) has shown great promise for the healing of meniscal tears, is grown from the patient’s own stem cells and will be transplanted in the patient’s knee joint within two weeks of extracting the stem cells from bone marrow.
The MHRA approved Phase I/IIa trial will treat ten meniscal tear patients with a cell bandage product, seeded with the patient's own stem cells. The trial will be undertaken at Southmead Hospital in Bristol and is scheduled to begin in May 2012 with interim data available within 18 months.
Azellon is co-founded by Professor Anthony Hollander at the University of Bristol, who came to national prominence as part of the academic team that saved the life of Claudia Castillio, after developing the first tissue-engineered trachea (windpipe) using the patient’s own stem cells. This fully functioning airway was transplanted into the patient and saved her life.
Professor Anthony Hollander, Chief Scientific Officer of Azellon Cell Therapeutics Ltd and Head of the School of Cellular and Molecular Medicine at the University of Bristol, said: “With permission for a trial from MHRA and completion of this funding round, we are now ready to get going on our safety trial; it’s an important moment for Azellon and for stem cell research.”
Alan Aubrey, CEO of IP Group plc, said: “Azellon’s stem cell bandage is targeted at a very large and growing market with a clear medical need and we are pleased to support the company as it moves into its Phase I/IIa trial.”
Hugh Osmond, who has a medical degree from Oxford University, said: “As a keen sportsman who has had multiple knee operations myself, I believe that this procedure has the potential to be a major breakthrough in treating knee and eventually other joint injuries. For many of the 1.7 million people a year who have operations to repair torn knee cartilage, it could be the difference between an active old age or spending their pension years in a wheel chair. I am very excited.”