tag:blogger.com,1999:blog-51518691163175385902024-03-13T12:37:24.967-04:00RALLY FOR ALIA CELEBRATION OF LIFE FOR LOVERS OF LIFEBrother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.comBlogger299125tag:blogger.com,1999:blog-5151869116317538590.post-82743177717395337932014-01-02T10:08:00.001-05:002014-01-02T10:08:23.720-05:00<div dir="ltr" style="text-align: left;" trbidi="on">
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ST. LOUIS, Mo. (Ivanhoe Newswire) -- Sickle cell is a serious disease that causes pain, anemia, infection, organ damage, and even stroke. It’s the most common inherited blood disorder in the U.S. The good news is bone marrow transplants can be a cure. The bad news is not every patient has a matching donor. Now, researchers are looking at a new way to offer more patients transplants.</div>
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Madisyn Travis is like any other nine-year-old, but there’s something that sets Madisyn apart. She has sickle cell, an inherited red blood cell disease.</div>
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“It makes me feel bad and sometimes I have to go to the hospital,” Madisyn told Ivanhoe.</div>
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“It’s really hard to see her life interrupted,” Denise Travis, Madisyn’s mom, told Ivanhoe.</div>
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However, soon Madisyn will get a bone marrow transplant to cure her disease. Her little brother or sister are both matches and one will be the donor.</div>
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Madisyn is one of the lucky ones. Only 14 percent of patients have a matching sibling.</div>
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“Ten years ago, we’d just tell them, ‘sorry you have no family member. We can’t transplant you,’” Shalini Shenoy, MD, Professor of Pediatrics, Medical Director, Pediatric Stem Cell Transplant Program, Washington University School of Medicine, St. Louis Children's Hospital, told Ivanhoe.</div>
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Dr. Shalini Shenoy is studying a new option for patients without related donors. Stem cells from a baby’s umbilical cord can be infused in the arm. They travel to the bone marrow, settle there, and make new cells.</div>
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“Now, with this, we can take another 30 percent or 40 percent to transplant,” Dr. Shenoy said.</div>
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Madisyn is excited about a cure and even though they annoy her at times, she’ll have her brother and sister to thank for it.</div>
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Sickle cell is more common in minorities, occurring in about one in every 500 African Americans and about one in every one-thousand Hispanic Americans.</div>
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So far, just three patients have been treated with the umbilical cord blood transplant using unrelated donor cord blood. Ten research centers across the country are participating in Dr. Shenoy’s study.</div>
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MEDICAL BREAKTHROUGHS</div>
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RESEARCH SUMMARY</div>
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TOPIC: STEM CELLS TO CURE SICKLE CELL</div>
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REPORT: MB #3717</div>
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BACKGROUND: Sickle cell disease is a disorder that has an effect on how red blood cells carry oxygen to the body. Normal red blood cells are rounded, but when a person has sickle cell disease, their red blood cells look like a crescent moon. The name “sickle cell” comes from the crescent shape of the cells. Sickled cells have a hard time moving through the blood vessels. They can get stuck and block blood vessels, which stops the oxygen from getting through. This is a painful disorder that may also cause harm to certain bones, organs, and muscles. Having the disease means a lifelong battle against the health problems it can cause, like pain, anemia, stroke, and infections. However, people are able to have a good quality of life by learning how to manage the disease. (Source: <a href="http://www.webmd.com/" style="color: #457d9d; font-size: 14px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: underline;">www.webmd.com</a>)</div>
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CAUSES: Sickle cell disease does not just develop; it is inherited from a parent. However, a child has to inherit two sickle cell genes, one from each parent. If a child carries the gene from only one parent, then they do not have sickle cell disease, just the sickle cell trait that they could pass on. (Source: <a href="http://www.webmd.com/" style="color: #457d9d; font-size: 14px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: underline;">www.webmd.com</a>)</div>
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TREATMENT: Early treatment includes daily antibiotics from two months to five years of age in order to prevent infections. Managing pain is a big part of treatment for sickle cell disease. Parents can plan for a painful event ahead of time by creating a pain management plan with the child’s doctor. Some people may need regular blood transfusions to lower the risk of stroke and treat anemia. (Source: <a href="http://www.webmd.com/" style="color: #457d9d; font-size: 14px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: underline;">www.webmd.com</a>)</div>
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NEW TREATMENT: Bone marrow transplants are usually used as a last-line of defense against cancer, especially leukemia. However, in the past ten years, non-cancerous diseases have gone from making up about 15 percent of all pediatric bone marrow transplants to 35 percent. In the mid-90s, transplants were found to be successful for patients suffering from severe sickle cell disease, but only if their tissue matched a sibling donor. Transplants from unrelated donors were found to be too toxic, requiring an excessive amount of chemotherapy and radiation. Researchers tried to use smaller doses of the chemicals, called “reduced intensity,” which resulted in patient’s bodies rejecting the transplants. Dr. Shenoy and colleagues continued testing the “reduced intensity” theory. Dr. Shenoy’s approach involved using antibodies that target proteins in the immune system and finding the amount of toxic chemicals that wipe out just enough of the body’s immunity to allow the graft to take over. Her approach was proved successful in treating sickle cell patients and other life-threatening metabolic and bone marrow failure disorders. About five years ago, it was adopted as the protocol for using transplants from unrelated donors to treat non-cancerous disorders. However, finding a match is still difficult. Dr. Shenoy says that you have a better chance at finding a cord match rather than a marrow. Adding one more immune-suppression drug to the mix, holds promise. Dr. Shenoy was granted approval to lead a cord-blood transplant study involving 10 research centers across the country. However, the study has a safety restriction: three patients must have successful transplant before moving on to the next three. (Source:<a href="http://www.stltoday.com/lifestyles" style="color: #457d9d; font-size: 14px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: underline;">http://www.stltoday.com/lifestyles</a>)</div>
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<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<em style="font-size: 14px; font-style: italic; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Shalini Shenoy, MD, Professor of Pediatrics, Medical Director, Pediatric Stem Cell Transplant Program, Washington University School of Medicine, St. Louis Children's Hospital, talks about a possible new treatment for sickle cell disease.</em></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Has treatment for sickle cell in the past few years been a bone marrow transplant from a relative?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy:</strong> Sickle cell symptoms can be controlled with either blood transfusions or hydroxyurea or medications that are supportive in general. However, they just help control symptoms of the disease and sometimes they are unable to do that even if given adequately. Then despite the best of transfusions or hydroxyurea, the disease progresses and the blood vessel damage continues. Transplantation is considered a cure because you’re replacing their blood cells completely with blood cells from a donor who does not have the disease. Thus, you are replacing their sickle red cells with normal red cells - something that will leave them cured of their disease.</div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Isn’t it amazing for a doctor to be able to say I’ve cured this disease?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy:</strong> Absolutely. This is a chronic disorder and they have to live with it for a lifetime. It is hard when they encounter complications from the disease; these actually increase as they grow older.</div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">What kind of complications?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy:</strong> It is progressive blood vessel damage that then begins to hurt vital organs. In the central nervous system it’s overt stroke or a silent stroke where brain changes from blood vessel damage leads to difficulties with their studies and in maintaining their IQ. An overt stroke could leave them partially paralyzed or have other neurologic deficits. If it affects the lung, then it causes what’s called acute chest syndrome especially when their younger. They have respiratory failure, and will often end up in the intensive care unit ( ICU), or as they grow older pulmonary hypertension is a big risk for mortality. Pulmonary hypertension can cause sudden death in patients with sickle cell disease. Other organs that are damaged include the bones, kidneys, eyes, etc.</div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">What’s the life expectancy?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy:</strong> The median time of survival for sickle cell disease is still 40 years for both men and women. That doesn’t mean that some people won’t survive for longer, but that is the survival period for the majority - the average lifespan they’re looking at, and this is despite all the care we are able to give them. This also doesn’t take into account those patients that survive longer but are left with a chronic disorder and are consistently in the hospital and have a poor quality of life. Often they are in chronic pain, and have multiple hospital admissions for all the complications that come with the disease. Yes, they survive the disease but at what cost? If you put all that together, the morbidity with this disease is quite high, not just the mortality.</div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Have you been curing it with a bone marrow transplant?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy:</strong> You can cure patients with a successful bone marrow transplant and this was first proven in the late 1990s.</div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">For yours, has it only been from a relative?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy:</strong> Transplant from a suitable relative or sibling is ideal because that’s the probably the safest with the best outcomes. That’s because if you have a relative that’s tissue matched like a brother or a sister, then it’s easy to get their cells to engraft in a patient. They have a low incidence and severity of a complication called graft versus host disease; this is due to donor immune cells coming into the transplant recipient (the patient_ and causing trouble because they are foreign to the patient. We started off studying transplants from brothers and sisters for this reason. It was shown that it was effective, and it cured the disease. It not only cured it, but improved previous organ damage in many cases.</div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Would it reverse the damage?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy: </strong> Yes, It could. It stabilized the damage first and then actually reversed it and made things better. It suggested that you could actually cure the disease and give potentially a normal lifespan without the morbidity of the disease. Then it was up to us to make transplant available to more people and try to get over the toxicities that the transplant came with.</div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">If you didn’t have a matching relative you’d have to transplant from a unrelated donor, that meant really harsh chemo and radiation?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy:</strong> That meant that your risks during the transplant were higher and one would have to find perhaps safer ways of transplanting them which is giving them something that they could tolerate and get the graft in. The way the first transplants were done was with what is called myeloablative chemotherapy, and that is using high doses of chemotherapy to ablate the marrow. The person who was getting the transplant got this chemotherapy and the marrow completely was emptied. Then the new cells were given they went in, they settled down, and they successfully made for a cure. But, when we did that we exposed them to a lot of chemotherapy and then as we followed them along the way there were a couple of things that were potential problems such as sterility, if they were in the age range where they were getting a growth spurt there was potential growth inhibition, etc. Not to mention the toxicities on their organs. If they had sickle cell disease related damage to the liver for example, or the lungs then the chemotherapy actually added to that toxicity and there was concern for liver dysfunction, veno-occlusive disease as it’s called in the liver. There were specific toxicities to the kidney, to the lung and so on, all potential problems. Thus, you had to be very careful about who you could take to transplant because you didn’t want to make transplant cause more organ damage. We tried to move on from there and give them conditioning therapy or a preparative regimen that was not necessarily myeloablative chemotherapy based - it was called a reduced intensity regimen, which could potentially be tolerated by even those people that had organ damage from their disease. There was a potential to maintain fertility as well. That was really important to some - because if you think about it, it’s a parent giving us permission to go ahead and transplant a young child who would probably be sterile as he/she grew up. This regimen was designed to reduce the toxicity during transplant and also potentially decrease some of the late effects that came with the myeloablative regimen that we were using.</div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">How did you do that?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy:</strong> We did that by backing off on the amount of chemotherapy we gave them and we used immunosuppressive medications like antibodies. What they did was suppress the patient’s immune system significantly to allow the new donor cells to come in and didn’t necessarily empty their marrow with chemotherapy. We backed off on the chemotherapy we gave them, we didn’t use any radiation and we used more monoclonal antibody type immunosuppressives to get the graft in. Now there are various protocols looking at reducing the intensity of conditioning and still getting engraftment. As soon as you reduce intensity what happens is the cells that are coming in are rejected by the patient. If you go too low then you get more graft rejection and so that leaves you back at baseline, you’re not curing the disease. There has to be a fine balance where you reduce the intensity just enough to be able to get the graft in but you don’t reduce it way too much where they get too much graft rejection. That’s one of the advances that’s happened since the first sibling donor transplant.</div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Now you’ve advanced on that, right?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy:</strong> We are testing a reduced intensity approach that became a protocol for unrelated donor transplant. We found that it was tolerated quite well by patients that were even in their late teens. The older your patient the more the toxicity of the transplant because they’ve had sickle related damage quite a bit. If you back off on the intensity we found that you could give it to older patients and they tolerated it quite well. As I said, there are now several protocols that took up the same idea and continue to improve upon it. The other question is how do we offer this treatment to more patients? What if you didn’t have a brother or sister that was a match? 10 years ago we just told them, sorry you have no family member we can’t transplant you. Now, if they have a suitable donor in the registry, and are eligible based on organ function and disease severity, they are able to go to transplant on this study. It is looking to define outcomes of unrelated donor transplants for sickle cell disease. When we first started that protocol we said cord bloods that were eligible (suitably matched) could be used for transplant. The criteria for matching cord blood are a little more lax than the criteria for matching bone marrow because the risks of graph versus host disease are lower with cord blood than they are marrow.</div>
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<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Are there any downsides?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy:</strong> The downside was increased graft rejection. If you go too low on the intensity of your conditioning cord will tend to be rejected faster than marrow would be. When we started the reduced intensity trial we took both marrows and cords and found along the way that the marrows engrafted but the cords didn't, so the protocol then was closed to cords and just left open for marrows. We went on to a more modified approach with cords and are now testing this. We had a baseline reduced intensity regimen that worked for bone marrow; we tweaked it a little bit more and now have a separate trial for cord blood transplants. We started off first with a transplant trial for thalassemia using this modified regimen. Thalassemia is another hemoglobinopathy which requires chronic transfusion therapy so it was sort of comparable to what sickle cell disease needed. For thalassemia, this turned out to be successful in getting engraftment even with cords. We’ve opened that now to sickle cell disease as well such that we are now doing reduced intensity transplants with cord blood as well, as a study.</div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Why wouldn’t you give this to everybody that has sickle cell?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy:</strong> First,finding a donor is the issue. If you didn’t have someone that was reasonably matched for the cord or very well matched for the bone marrow then there was no suitable donor available. Only 14% of patients will have a suitably matched sibling donor. Another 30-40% can potentially find marrow or cord products. Others may consider transplant on newer protocols looking at transplanting patients from family members that are half-matched. Most of these transplants now are being performed in reduced intensity fashion. Given the risks of transplant such as infections when the immune system is suppressed, the risk of graft versus host disease, or organ damage and a risk of death of any of these complications, we should be careful about choosing our transplant candidates carefully – only those with severe disease – especially if they have no matched sibling donors.</div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">So</strong> <strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">there’s still 40% that aren’t eligible for transplant. Why is that?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy:</strong> If they don’t have a good donor, we just can’t take someone to transplant.</div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">You’re taking non-relatives, but they’re still a match?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy: </strong> Correct. So it’s not a blood type match, there’s something called an HLA match which is a tissue match. It is a tissue protein and there are a group of these proteins that are important from the transplant perspective. We know what the important ones are and those need to be matched for someone to be a good donor for a patient. That’s what the registries do for us. These are voluntary donors registries that have millions of donors saying if I can help somebody I will, please access me, so they sign-up to be on the registry. The registry maintains this huge database of who’s in there and who would like to donate. When we have a patient we contact the registry and say, here’s the HLA type of our patient and the disease. We ask who they have in the registry that could be a potential match. The majority of people on the registry are Caucasian and it is not a very diverse. Efforts are being made to increase the diversity because these HLA types often run true to race. If I have a Caucasian patient the likelihood of my finding a donor is much higher than if I have a minority patient. This is why we are trying to expand the registries to increase the pool of both marrow donors and cord blood products - to try to increase the number of people that can benefit from the registries.</div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Part of this talks about bone marrow transplants and then some of it talks about stem cells. Is that the stem cells from the bone marrow?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy:</strong> Right. Stem cell is any cell that can go in, settle in the bone marrow, and make new blood cells. Those can come from the bone marrow, peripheral blood, or cord blood. We don’t use peripheral blood too much currently because the risk of graft versus host disease is higher. Our preference is to use bone marrow or cord blood. The donor cells need to be suitably HLA matched and then we can access the donor. This is all done anonymously by the registry. Say we have a patient who has sickle cell disease that could use your product, “would you be willing to donate and would you be willing to donate bone marrow?” Most donors are nice enough to say I will do whichever the center would prefer because I joined the registry to help. So we ask for morrow preferentially.</div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Are you going to fight for that bone marrow because every disease is now using stem cells in bone marrow? Is it really hard to get enough?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy:</strong> If we access a donor, say the donor was identified as being a good one for this patient, that person is taken off the registry and is no longer available to others. Multiple people won’t be accessing a single donor. It happens once and is very systematically handled. The registry is lists all the other people that haven’t donated yet so that’s how it works. We never come into contact with the donor to keep this free of bias; this is all very voluntary. The registry contacts the donor, we don’t even know where the donor is or who it is, it’s all anonymous. The donor donates and the product is shipped over to us, it comes on a flight to us and then we infuse it. The donor and recipient can arrange to meet at the end of 1 year after transplant if they wish.</div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Is this exciting to you?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy:</strong> Absolutely. When I first meet a patient our conversation is more about the transplant as a possibility. Our second meeting is usually after that search has been done and then we can sit down and talk more specifics.</div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">For these people they’re done with sickle cell then right, will these people who have spent half their life in the hospital have to come back to the hospital again?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy:</strong> The curedoesn’t happen overnight. Once the transplant is done it takes a while. The blood cells come up pretty quickly but it takes a while for the immune system to recover. We have to wait for the immune system and that takes the better part of that first year. There are a lot of restrictions, lot of hospital visits, and a lot of care, requirement for compliance, and a lot of medications. It’s not like, “I got my transplant and now I’m home free”. We are very careful to make sure they understand how the process goes.</div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Is it just like for an organ donor, do they have to stay on transplant drugs for the rest of their life?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy:</strong> Not for the rest of their lives, only until they are at risk for graft versus host disease. That’s the advantage we have over the organ transplant folks. This is not for life you don’t have to keep taking these medications for life to keep the organ in. It is taken to prevent graft versus host disease - until that risk is not there anymore.</div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">How long is that usually?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy:</strong> Generally about a year to a year and a half. Some of them will have longer need for immunosuppression because they have ongoing graft versus host disease, but the majority of them come off their medications generally between one and two years post-transplant.</div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Now just a short description, do you inject the transplant, how do you get it into the body?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy:</strong> It’s given through a IV. They have a central line, it’s given like a blood transfusion. It’s an anti-climax because that’s the day of transplant and everybody is here, the family is here, everybody is watching. It’s basically a bag that looks like blood.</div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">How long does it take?</strong></div>
<div style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<strong style="font-size: 14px; font-weight: bold; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Dr. Shenoy:</strong> It depends on the volume, it could take an hour or two but it just flows in. The fascinating part is that these cells know where to go. You’re just giving them in a blood vessel but they go directly to the bone marrow, settle there and make new cells. It will change the blood type of the patient, so the patient thought they were O or something but the donor was an AB, that’s what they’re going to be. They’re going to be typing as an AB for the future. Their whole blood picture changes over to what the donor looked like.</div>
<div align="center" style="font-size: 14px; line-height: 17px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 18px; padding-left: 5px; padding-right: 5px; padding-top: 5px;">
<em style="font-size: 14px; font-style: italic; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">This information is intended for additional research purposes only. It is not to be used as a prescription or advice from Ivanhoe Broadcast News, Inc. or any medical professional interviewed. Ivanhoe Broadcast News, Inc. assumes no responsibility for the depth or accuracy of physician statements. Procedures or medicines apply to different people and medical factors; always consult your physician on medical matters.</em></div>
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Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-19738414632281431922013-12-30T11:34:00.001-05:002013-12-30T11:34:03.101-05:00<div dir="ltr" style="text-align: left;" trbidi="on">
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People to Watch: Stem-cell researcher aims to kill root of cancer recurrence</h1>
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The young researcher has found a way to deactivate the gene responsible for tumour growth and regeneration.</h2>
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Stem-cell researcher Antonija Kreso takes her first selfie.</div>
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Antonija Kreso is pioneering a new way to treat cancer.</div>
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The 27-year-old University of Toronto med student has spent the past five years researching the characteristics of colon cancer stem cells. In the process, she has discovered that it is possible to deactivate the gene responsible for tumour growth and regeneration.</div>
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In 2014, she will continue her work at a downtown Toronto lab near Bay and College Sts., screening dozens of drugs to see which are most effective at killing the cancer cells permanently.</div>
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“She did most of this work almost single-handedly in terms of developing this whole approach,” says Dr. John Dick, the internationally renowned stem-cell biologist at Princess Margaret Cancer Centre in Toronto. Twenty years ago, Dick was the first to identify cancer stem cells in leukemia.</div>
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<li data-video-desc="Kimm Fletcher, of Milton, discusses her meeting with Ontario Health Minister Deb Matthews. Fletcher is fighting to get the cancer drug Avastin." data-video-id="2784968986001" data-video-title="Cancer patient's last chance" data-video-url="http://www.thestar.com/news/2013/10/30/cancer_patient_s_last_chance.html" style="background-attachment: initial; background-clip: initial; background-color: transparent; background-image: initial; background-origin: initial; background-position: initial initial; background-repeat: initial initial; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-color: rgb(204, 204, 204) !important; border-top-style: dotted !important; border-top-width: 0px !important; cursor: pointer; font-size: 14px !important; height: 113px; line-height: 1.35 !important; list-style-type: none !important; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 1em; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 1em; padding-right: 0px; padding-top: 0px !important; position: relative; text-indent: -1em; vertical-align: baseline; width: 170px;"><img alt="Cancer patient's last chance" src="http://www.thestar.com/content/dam/thestar/news/2013/10/30/cancer_patient_s_last_chance/2784968986001_videoStillImage.jpg.size.medium2.promo.jpg" style="background-attachment: initial; background-clip: initial; background-color: transparent; background-image: initial; background-origin: initial; background-position: initial initial; background-repeat: initial initial; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; display: block; font-size: 14px; height: 113px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline; width: 170px;" /><a class="caption" href="" style="background-attachment: initial; background-clip: initial; background-color: rgba(0, 0, 0, 0.597656); background-image: url(http://www.thestar.com/etc/designs/thestar/images/sprites.png); background-origin: initial; background-position: -1147px -175px; background-repeat: no-repeat no-repeat; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; bottom: 0px; color: rgb(255, 255, 255) !important; font-family: Helvetica, Arial, sans-serif; font-size: 12px; font-weight: bold; left: 0px; line-height: 1.2; margin-bottom: auto; margin-left: auto; margin-right: auto; margin-top: auto; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 9px; padding-left: 35px; padding-right: 9px; padding-top: 9px; position: absolute; right: 0px; text-decoration: none; vertical-align: baseline;"><span style="background-attachment: initial; background-clip: initial; background-color: transparent; background-image: initial; background-origin: initial; background-position: initial initial; background-repeat: initial initial; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 12px; height: 1px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; overflow-x: hidden; overflow-y: hidden; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; position: absolute; top: -10px; vertical-align: baseline; width: 1px;">Video:</span>Cancer patient's last chance</a></li>
<li data-video-desc="Houda Rafle, 28, battled advanced cancer after a Trillium radiologist missed seeing a tumour near her heart on a CT scan. She passed away on Wednesday." data-video-id="2670994537001" data-video-title="Houda Rafle misdiagnosed cancer patient" data-video-url="http://www.thestar.com/news/2013/09/13/houda_rafle_misdiagnosed_cancer_patient.html" style="background-attachment: initial; background-clip: initial; background-color: transparent; background-image: initial; background-origin: initial; background-position: initial initial; background-repeat: initial initial; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-color: rgb(204, 204, 204) !important; border-top-style: dotted !important; border-top-width: 0px !important; cursor: pointer; font-size: 14px !important; height: 113px; line-height: 1.35 !important; list-style-type: none !important; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 1em; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 1em; padding-right: 0px; padding-top: 0px !important; position: relative; text-indent: -1em; vertical-align: baseline; width: 170px;"><img alt="Houda Rafle misdiagnosed cancer patient" src="http://www.thestar.com/content/dam/thestar/news/2013/09/13/houda_rafle_misdiagnosed_cancer_patient/2670994537001_videoStillImage.jpg.size.medium2.promo.jpg" style="background-attachment: initial; background-clip: initial; background-color: transparent; background-image: initial; background-origin: initial; background-position: initial initial; background-repeat: initial initial; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; display: block; font-size: 14px; height: 113px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline; width: 170px;" /><a class="caption" href="" style="background-attachment: initial; background-clip: initial; background-color: rgba(0, 0, 0, 0.597656); background-image: url(http://www.thestar.com/etc/designs/thestar/images/sprites.png); background-origin: initial; background-position: -1147px -175px; background-repeat: no-repeat no-repeat; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; bottom: 0px; color: rgb(255, 255, 255) !important; font-family: Helvetica, Arial, sans-serif; font-size: 12px; font-weight: bold; left: 0px; line-height: 1.2; margin-bottom: auto; margin-left: auto; margin-right: auto; margin-top: auto; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 9px; padding-left: 35px; padding-right: 9px; padding-top: 9px; position: absolute; right: 0px; text-decoration: none; vertical-align: baseline;"><span style="background-attachment: initial; background-clip: initial; background-color: transparent; background-image: initial; background-origin: initial; background-position: initial initial; background-repeat: initial initial; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 12px; height: 1px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; overflow-x: hidden; overflow-y: hidden; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; position: absolute; top: -10px; vertical-align: baseline; width: 1px;">Video:</span>Houda Rafle misdiagnosed cancer patient</a></li>
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“She’s incredibly gifted,” says Dick, who was Kreso’s PhD advisor and with whom she will continue to work in 2014.</div>
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Earlier this month, the respected medical journal <a href="http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3418.html" style="background-attachment: initial; background-clip: initial; background-color: transparent; background-image: initial; background-origin: initial; background-position: initial initial; background-repeat: initial initial; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #0072bc; font-size: 14px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;" target="_blank">Nature Medicine </a>published the results of her latest work. She was lead author on a study that used a small-molecule inhibitor — a drug — that made it impossible for the cancer stem cells transplanted in mice to self-renew.</div>
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“In other words,” Dick said, “the cancer was permanently shut down.”</div>
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In the new year, with guidance from Dick and Dr. Catherine O’Brien — a surgeon who inspired Kreso to pursue a medical degree — the young scientist will screen about 50 more drugs provided by the Structural Genomics Consortium in the hunt for additional targeted cancer treatments.</div>
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Based out of the MaRS complex, Kreso splits her time between her academic work and research, thanks to several scholarships.</div>
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“I think it’s definitely the way of the future,” says Kreso, who grew up in Hamilton, the daughter of a Croatian electrician and seamstress. She begins her third year of medical school in 2014 and hopes to specialize in surgery.</div>
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“By going after these cancer stem cells with very targeted molecules, we’re shrinking the tumour and getting rid of the key cells. The number one reason why patients die is because the cancer comes back. You can cut out a tumour very easily, give radiation and the patient will be fine but five, 10 years later the cancer comes back. This is really what our work is trying to address.</div>
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“We’re really targeting the root of the cancer.”</div>
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Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-82190423415945581442013-12-10T13:35:00.001-05:002013-12-10T13:35:05.958-05:00<div dir="ltr" style="text-align: left;" trbidi="on">
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Scientist muscle in on stem cell therapy</h1>
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<img alt="Monash University's Australian Regenerative Medicine Institute can now isolate and make precursor skeletal m..." height="366" src="http://resources0.news.com.au/images/2013/12/09/1226779/235016-a5a1d5a6-60ba-11e3-be16-1445237cc09f.jpg" style="border-bottom-style: none; border-bottom-width: 0px; border-color: initial; border-color: initial; border-left-style: none; border-left-width: 0px; border-right-style: none; border-right-width: 0px; border-style: initial; border-top-style: none; border-top-width: 0px; border-width: initial; box-sizing: border-box; display: block;" width="650" /></div>
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<span class="caption-text" style="box-sizing: border-box;">Monash University's Australian Regenerative Medicine Institute can now isolate and make precursor skeletal muscle cells.</span> <span class="image-source" style="box-sizing: border-box;"><em style="box-sizing: border-box;">Source:</em> HeraldSun</span></div>
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<strong style="box-sizing: border-box; font-weight: bold;">MELBOURNE scientists have made a world-first stem cell breakthrough that brings muscle repair and regeneration one step closer to reality.</strong></div>
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Monash University's Australian Regenerative Medicine Institute can now isolate and make precursor skeletal muscle cells, which form the muscles in our body.</div>
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They have discovered a more efficient way to make them from human pluripotent stem cells, which have the ability to become any cell in the body.</div>
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The breakthrough will have immediate benefits, allowing researchers to conduct large scale trials for drugs to treat degenerative diseases.</div>
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"The other real significance of our finding is that we can also isolate the precursor cells helping us towards the ultimate goal of using them for transplantation for muscle-wasting diseases such as muscular dystrophy," Associate Professor Tiziano Barberi said.</div>
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It could also eventually also assist regeneration of the muscle in patients who lose it through trauma or cancer.</div>
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"There is an urgent need to find a source of muscle cells that could be used to replace defective muscle fibres in degenerative disease and these precursor muscle cells could be the source," he said.</div>
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Associate Professor Barberi was the first to derive skeletal muscle cells from human pluripotent stem cells in 2007.</div>
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Human pluripotent stem cells are a promising resource for use in cell-based therapies and for studying disease in a dish, but despite advancements making skeletal muscle has been a challenge.</div>
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Together with PhD student Bianca Borchin he has now developed a new effective method of generating these cells.</div>
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They used a technique called fluorescence activated cell sorting (FACS).</div>
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It allowed them to identify the protein markers in muscle precursor cells so they can single them out from the cell cultures.</div>
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He said the problem with mature cells was that they had little benefit in transplants because they would not create new muscle.</div>
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"If you transplant the mature cells you may get some temporary repair, but if you use precursor cells they will repair the fibres and some will also act as reserve to repair the cells each time new muscle is needed."</div>
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Ms Borchin said the results marked a significant step towards the use of pluripotent stem cells for muscle repair.</div>
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Associate Professor Barberi said they would now need to test the cells in animal models of the disease to see if they are effective.</div>
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The research was published in the journal Stem Cell Reports.</div>
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Lucie.vandenberg@news.com.au</div>
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Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-5456966714380925882013-12-10T13:33:00.001-05:002013-12-10T13:33:27.205-05:00<div dir="ltr" style="text-align: left;" trbidi="on">
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Novel Drug Regimen Can Improve Stem Cell Transplantation Outcomes</h1>
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December 9, 2013</div>
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<strong style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 12px; font-weight: bold; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Bortezomib (Velcade) reduces GVHD, boosts survival</strong></div>
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Adding bortezomib (Velcade) to standard preventive therapy for graft-versus-host-disease (GVHD) results in improved outcomes for patients receiving stem-cell transplants from mismatched and unrelated donors, according to researchers from Dana-Farber Cancer Institute.</div>
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In a new phase 2 trial, patients treated with bortezomib had lower rates of severe acute GVHD and treatment-related mortality, and experienced better one-year overall survival than has been seen historically with such patients receiving standard preventive therapy, the investigators reported at the American Society of Hematology annual meeting.</div>
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“This regimen appears to improve not just GVHD prevention but more importantly, overall and relapse-free survival for myeloablative transplant recipients lacking matched sibling donors,” said John Koreth, MBBS, DPhil, of Dana-Farber, the lead author and study PI. The senior author is Edwin P. Alyea, III, MD, also of Dana-Farber.</div>
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Stem cell transplantation following myeloablation (high-dose chemotherapy to wipe out the patient’s bone marrow and immune system) is a curative therapy in advanced or aggressive hematologic malignancies, Koreth said. However, recipients who lack preferred matched sibling donors have worse outcomes, with higher treatment-related mortality and severe GVHD, and poorer survival.</div>
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Bortezomib, a proteasome inhibitor drug, is a mainstay of treatment for multiple myeloma. In addition to killing cancer cells, bortezomib dampens some immune responses, suggesting it may have a role in mitigating GVHD, the result of donor immune cells attacking the transplant recipient’s normal tissues.</div>
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The prospective, single-arm phase 2 trial of a bortezomib-based regimen enrolled 34 patients with hematologic malignancies who received myeloablative stem cell transplants. In addition to standard GVHD prophylaxis medications – tacrolimus and methotrexate – the patients received three doses of bortezomib (on the first, fourth and seventh day after transplant). The treatment was well-tolerated with no patients missing doses because of toxicity.</div>
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Historically, recipients of unrelated and mismatched donor transplants have severe acute GVHD rates of 28 percent and 37 percent, respectively, with one-year treatment-related mortality of 36 percent and 45 percent, respectively, and one-year overall survival of 52 percent and 43 percent, respectively.</div>
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In patients treated with bortezomib in the new study, the rate of severe acute GVHD at 180 days after transplant was only 12 percent. By two years, only 8.8 percent of patients had died from treatment-related mortality, and 5.9 percent had died from disease relapse. Overall survival at two years was high at 84 percent.</div>
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Koreth said that a randomized trial of bortezomib for GVHD prevention is ongoing at Dana-Farber.</div>
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<br /><span style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-size: 12px; font: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: initial; outline-width: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Read more at <a href="http://www.redorbit.com/news/health/1113023391/novel-drug-regimen-can-improve-stem-cell-transplantation-outcomes/#1OhxReI92DZh4hvs.99" style="background-attachment: initial; background-clip: initial; background-color: transparent; background-image: initial; background-origin: initial; background-position: initial initial; background-repeat: initial initial; color: #003399; font-size: 12px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">http://www.redorbit.com/news/health/1113023391/novel-drug-regimen-can-improve-stem-cell-transplantation-outcomes/#1OhxReI92DZh4hvs.99</a></span></div>
Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-11339102539948875152013-12-03T20:17:00.001-05:002013-12-03T20:17:35.992-05:00domain-b.com : Researchers unlock a new means of growing intestinal stem cells<a href="http://www.domain-b.com/technology/biotech_pharma/20131203_diabetes.html">domain-b.com : Researchers unlock a new means of growing intestinal stem cells</a>Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-18283550545219616092013-12-03T19:51:00.001-05:002013-12-03T19:51:36.972-05:00Toronto researchers stop colon cancer stem cells from regenerating<a href="http://metronews.ca/news/toronto/870840/toronto-researchers-have-success-preventing-colon-cancer-stem-cells-from-regenerating/">Toronto researchers stop colon cancer stem cells from regenerating</a>Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-84904280482202868732013-10-27T12:02:00.001-04:002013-10-27T12:02:59.099-04:00<div dir="ltr" style="text-align: left;" trbidi="on">
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Stem cell therapy not effective nor safe for diabetes, doctors say</h1>
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Shown is a tray containing stem cells. (AFP)</div>
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<a href="http://www.interaksyon.com/" style="color: #960b12;" title="InterAksyon.com">InterAksyon.com</a><br />The online news portal of TV5</div>
Stem cell therapy--or introducing fresh cells that can regenerate to help treat disease--remains an experimental treatment for those suffering from Type 1 and Type 2 diabetes.<br />
Experts from the the Philippine Society of Endocrinology and Metabolism (PSEM) made this announcement during a press conference held on Tuesday, saying that "no conclusive evidence that stem cell therapy is effective and safe for diabetes."<br />
"As such, it cannot be made available to individuals with diabetes as a standard treatment like the usual drug prescriptions. Stem cell can only be given to individuals with diabetes under controlled conditions such as, under experimental protocols of clinical trials," a statement from the PSEM said, quoting Dr. Cecilia Jimeno, PSEM President.<br />
PSEM, a subspecialty organization under the Philippine College of Physicians, as well as the PCP itself, belong to a coalition of other medical societies, academic institutions and other health groups that have organized themselves to educate the public about stem cell therapy.<br />
The coalition maintains that the effectiveness and safety of stem cell have unproven indications yet on heart, lung, neurologic, rheumatologic, kidney and gastrointestinal diseases, diabetes mellitus, hypertension, autism, cancer, aging and aesthetics, HIV, AIDS, and other conditions.<br />
These groups have issued a public advisory to caution diabetes patients and their families who may be "vulnerable to exploitation," the statement said.<br />
"Other types involve claims using anecdotes advertised and endorsed by well-known personalities who have no scientific credibility to make such claim, except for his or her limited experience. The public needs protection from this unethical use of still unproven therapy which may have unknown and unquantified harmful effects. For PCP, exposing our patients to these unknown risks is ethically unacceptable," Dr. Priscilla Caguioa, PCP President, said in the same statement.<br />
Patients receiving stem cell therapy under clinical trials should not pay for these experimental treatments and must sign an informed consent form that explains the procedure, its benefits, and possible harms, the statement said.<br />
The PSEM together with the Philippine College of Physicians (PCP) expressed concern that patients who are usually very sick may easily be swayed to use unproven therapies because of the hope for cure.<br />
Under Food and Drug Administration (FDA) Circular No. 2013-020 dated August 13, 2013, only hematopoietic stem cell transplantation, corneal resurfacing with limbal stem cells, and skin regeneration with epidermal stem cells for burns are the three standards of health care that are generally recognized by the Food and Drug Administration, the statement said.<br />
“Stem cell provides medical practitioners an innovative approach to restore health and offers the patients alternative choices. However, the promise of stem cell therapy must be backed by science- and evidence-based medicine, before it can be part of the standard health care. Any clinical use of stem cell products outside of the FDA-approved indications is illegal,” Jimeno added.<br />
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Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-84839445026164736052013-10-10T14:36:00.001-04:002013-10-10T14:36:05.972-04:00<div dir="ltr" style="text-align: left;" trbidi="on">
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Harvard Stem Cell Institute publishes first clinical trial results</h1>
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<img height="220px" src="http://www.hsci.harvard.edu/system/files/slideshow-images/CutlerZonSquare.jpg" style="border-bottom-width: 0px; border-color: initial; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 11px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;" width="220px" /><div class="caption" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 11px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">
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Corey Cutler (left) and Leonard Zon (right) were part of the team that brought a compound found to expand blood stem cell populations in zebrafish to human clinical trials.</div>
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<strong style="font-weight: bold;"><span class="date-display-single" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">October 8, 2013</span></strong></div>
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Starting with a discovery in zebrafish in 2007, <a href="http://www.hsci.harvard.edu/" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #0077c3; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: bold; letter-spacing: 0.05em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">Harvard Stem Cell Institute</a> (HSCI) researchers have published initial results of a Phase Ib human clinical trial of a therapeutic that has the potential to improve the success of blood stem cell transplantation. This marks the first time, just nine short years after Harvard’s major commitment to stem cell biology, that investigators have carried a discovery from the lab bench to the clinic—fulfilling the promise on which HSCI was founded.</div>
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The Phase 1b safety study, published in the journal <a class="ext" href="http://bloodjournal.hematologylibrary.org/content/early/2013/08/30/blood-2013-05-503177.abstract" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #0077c3; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: bold; letter-spacing: 0.05em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;"><em style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: italic; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Blood</em></a><span class="ext" style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: url(http://www.hsci.harvard.edu/sites/all/modules/extlink/extlink.png); background-origin: initial; background-position: 100% 50%; background-repeat: no-repeat no-repeat; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 12px; padding-top: 0px; vertical-align: baseline;"></span>, included 12 adult patients undergoing umbilical cord blood transplantation for leukemia or lymphoma at the <a class="ext" href="http://www.dana-farber.org/" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #0077c3; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: bold; letter-spacing: 0.05em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">Dana Farber Cancer Institute</a><span class="ext" style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: url(http://www.hsci.harvard.edu/sites/all/modules/extlink/extlink.png); background-origin: initial; background-position: 100% 50%; background-repeat: no-repeat no-repeat; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 12px; padding-top: 0px; vertical-align: baseline;"></span> and <a class="ext" href="http://www.massgeneral.org/" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #0077c3; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: bold; letter-spacing: 0.05em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">Massachusetts General Hospital</a><span class="ext" style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: url(http://www.hsci.harvard.edu/sites/all/modules/extlink/extlink.png); background-origin: initial; background-position: 100% 50%; background-repeat: no-repeat no-repeat; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 12px; padding-top: 0px; vertical-align: baseline;"></span>. Each of the patients received two umbilical cord blood units, one untreated and another treated with the small molecule, 16,16 dimethyl prostaglandin E2 (dmPGE2). All 12 patients had reconstitution of their immune systems and renewed blood formation, and 10 of the 12 patients had blood formation derived solely from the dmPGE2-treated umbilical cord blood unit.</div>
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The clinical testing is now entering Phase II, which will assess the treatment’s efficacy at 8 medical centers with 60 patients. Results are expected within 18-24 months.</div>
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Like much of the work conducted under the HSCI umbrella, this “first” depended upon the collaboration of scientists at different Harvard-affiliated institutions, and, in this case, an industrial partner:</div>
<ul style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; list-style-type: none; margin-bottom: 1em; margin-left: 1em; margin-right: 1em; margin-top: 1em; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">
<li style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; list-style-position: outside; list-style-type: disc; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">The initial finding occurred in the laboratory of <a class="ext" href="http://zon.tchlab.org/" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #0077c3; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: bold; letter-spacing: 0.05em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">Leonard Zon, MD</a><span class="ext" style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: url(http://www.hsci.harvard.edu/sites/all/modules/extlink/extlink.png); background-origin: initial; background-position: 100% 50%; background-repeat: no-repeat no-repeat; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 12px; padding-top: 0px; vertical-align: baseline;"></span>, chair of the HSCI Executive Committee and Professor of Stem Cell and Regenerative Biology at Harvard, who studies blood formation in zebrafish at <a class="ext" href="http://www.childrenshospital.org/" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #0077c3; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: bold; letter-spacing: 0.05em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">Boston Children’s Hospital</a><span class="ext" style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: url(http://www.hsci.harvard.edu/sites/all/modules/extlink/extlink.png); background-origin: initial; background-position: 100% 50%; background-repeat: no-repeat no-repeat; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 12px; padding-top: 0px; vertical-align: baseline;"></span>;</li>
<li style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; list-style-position: outside; list-style-type: disc; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Clinical research was conducted at Dana-Farber Cancer Institute and Massachusetts General Hospital, led by hematologic oncologist and HSCI Affiliated Faculty member <a class="ext" href="http://doctors.dana-farber.org/directory/profile.asp?pict_id=0000485" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #0077c3; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: bold; letter-spacing: 0.05em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">Corey Cutler, MD, MPH</a><span class="ext" style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: url(http://www.hsci.harvard.edu/sites/all/modules/extlink/extlink.png); background-origin: initial; background-position: 100% 50%; background-repeat: no-repeat no-repeat; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 12px; padding-top: 0px; vertical-align: baseline;"></span>; and</li>
<li style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; list-style-position: outside; list-style-type: disc; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;"><a class="ext" href="http://fatetherapeutics.com/" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #0077c3; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: bold; letter-spacing: 0.05em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">Fate Therapeutics, Inc.</a><span class="ext" style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: url(http://www.hsci.harvard.edu/sites/all/modules/extlink/extlink.png); background-origin: initial; background-position: 100% 50%; background-repeat: no-repeat no-repeat; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 12px; padding-top: 0px; vertical-align: baseline;"></span>, a San Diego-based biopharmaceutical company of which Zon is a founder, sponsored the Investigational New Drug application, under which the clinical program was conducted, and translated the research findings from the laboratory into the clinical setting.</li>
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“The exciting part of this was the laboratory, industry, and clinical collaboration, because one would not expect that much close interplay in a very exploratory trial,” Cutler said. “The fact that we were able to translate someone’s scientific discovery from down the hall into a patient just a few hundred yards away is the beauty of working here.”</div>
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Gastroenterologists have studied dmPGE2 for decades, because of its ability to protect the intestinal lining from stress. However, its ability to amplify stem cell populations—the first molecule discovered in any system to have such an effect—was identified in 2005 during a chemical screen exposing 5,000 known drugs to zebrafish embryos. That work, published in the journal <em style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: italic; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;"><a class="ext" href="http://www.nature.com/nature/journal/v447/n7147/abs/nature05883.html" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #0077c3; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: bold; letter-spacing: 0.05em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">Nature</a><span class="ext" style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: url(http://www.hsci.harvard.edu/sites/all/modules/extlink/extlink.png); background-origin: initial; background-position: 100% 50%; background-repeat: no-repeat no-repeat; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 12px; padding-top: 0px; vertical-align: baseline;"></span></em> in 2007, was conducted by two former Zon postdoctoral fellows, and current HSCI Principal Faculty members, <a class="ext" href="http://www.fishing4stemcells.org/" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #0077c3; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: bold; letter-spacing: 0.05em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">Wolfram Goessling, MD, PhD, and Trista North, PhD</a><span class="ext" style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: url(http://www.hsci.harvard.edu/sites/all/modules/extlink/extlink.png); background-origin: initial; background-position: 100% 50%; background-repeat: no-repeat no-repeat; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 12px; padding-top: 0px; vertical-align: baseline;"></span>.</div>
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“We were interested in finding a chemical that could amplify blood stem cells and we realized looking at zebrafish embryos that you could actually see blood stem cells budding from the animal’s aorta,” Zon said. “So, we elected to add chemicals to the water of fish embryos, and when we took them out and stained the aortas for blood stem cells, there was one of the chemicals, which is this 16,16 dimethyl prostaglandin E2, that gave an incredible expansion of stem cells—about a 300 to 400 percent increase.”</div>
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The dramatic effects of this molecule on blood stem cells made Zon, a pediatric hematologist, consider ways in which the prostaglandin could be applied to bone marrow transplantation, often used to treat blood cancers, including leukemia and lymphoma. Bone marrow contains the body’s most plentiful reservoir of blood stem cells, and so patients with these conditions may be given bone marrow transplants to reconstitute their immune systems after their cancer-ravaged systems are wiped out with chemotherapy and radiation.</div>
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Zon designed a preclinical experiment, similar to the one later done with cord blood patients, in which mice undergoing bone marrow transplants received two sets of competing bone marrow stem cells, one set treated with dmPGE2 and a second untreated set.</div>
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“What we found was the bone marrow stem cells that were treated with prostaglandin, even for just two hours, had a four times better chance of engrafting in the recipient’s marrow after transplant,” he said. “I was very excited to move this into the clinic because I knew it was an interesting molecule.”</div>
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Zon and his team’s next step was to visit Dana Farber Cancer Institute (DFCI), where they presented the mouse research at bone marrow transplant rounds and found physicians interested in giving the prostaglandin to patients.</div>
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“We basically sat down in a room and we brainstormed a clinical trial based on their scientific discovery, right then and there,” said Farber oncologist Corey Cutler. “They knew that it was something they could bring to the clinic, but they just didn’t know where it would fit. We said, if this molecule does what you say it does, significant utility would lie in umbilical cord blood transplants.”</div>
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A cord blood transplant is similar to a bone marrow transplant, however the blood stem cells are derived from the umbilical cord blood of a newborn, rather than from an adult donor. One of the advantages of umbilical cord blood is that matching between donor and recipient does not need to be as exact because potentially fatal graft-versus-host disease is less common. Although about 10-20 percent of stem cell transplantation procedures now use umbilical cord blood, the downside is that engraftment is more difficult, because the number of stem cells in an umbilical cord blood donation is far fewer than in an adult stem cell donation.</div>
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Umbilical cord blood transplants fail about 10 percent of the time; so increasing the procedure’s success would significantly help patients who do not have adult bone marrow donors, including a disproportionate number of non-Caucasian patients in North America. Increasing the engraftment rate would also allow the use of smaller umbilical cord blood units that are potentially better matches to their recipients, increasing the number of donations that go on to help patients.</div>
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Once the go-ahead for the trial was received by Fate Therapeutics from the <a class="ext" href="http://www.fda.gov/" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #0077c3; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: bold; letter-spacing: 0.05em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">US Food and Drug Administration</a><span class="ext" style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: url(http://www.hsci.harvard.edu/sites/all/modules/extlink/extlink.png); background-origin: initial; background-position: 100% 50%; background-repeat: no-repeat no-repeat; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 12px; padding-top: 0px; vertical-align: baseline;"></span>, and the DFCI Institutional Review Board, the umbilical cord blood processing was done by Dana-Farber's <a class="ext" href="http://www.dfhcc.harvard.edu/core-facilities/cell-manipulation/" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #0077c3; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: bold; letter-spacing: 0.05em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">Cell Manipulation Core Facility</a><span class="ext" style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: url(http://www.hsci.harvard.edu/sites/all/modules/extlink/extlink.png); background-origin: initial; background-position: 100% 50%; background-repeat: no-repeat no-repeat; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 12px; padding-top: 0px; vertical-align: baseline;"></span>, directed by HSCI Executive Committee member Jerome Ritz, MD. The study hit a stumbling block, however, once the human trial was underway with the first nine patients. The protocol that produced the dramatic blood stem cell expansion in mice did not translate to improved engraftment in humans.</div>
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“The initial results were very disappointing,” Cutler said. “We went back to the drawing board and tried to figure out why, and it turned out some of the laboratory-based conditions were simply not optimized, and that was largely because when you do something in the lab, the conditions are a little bit different than when you do it in a human.”</div>
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Fate Therapeutics discovered that the human cord blood was being handled at temperatures too cold (4-degrees Celsius) for the prostaglandin to biologically activate the stem cells and improve their engraftment properties. Fate further demonstrated that performing the incubation of the hematopoietic stem cells at 37-degrees Celsius and increasing the incubation time from 1 hour to 2 hours elicited a much stronger gene and protein expression response that correlated with improved engraftment in animal models.</div>
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In running a second cohort of the Phase Ib trial, which included 12 patients, dmPGE2 appeared to enhance the engraftment properties of the blood stem cells in humans and was deemed safe to continue into Phase II. “It’s probably the most exciting thing I’ve ever done,” Zon said. “Basically, to watch something come from your laboratory and then go all the way to a clinical trial is quite remarkable and very satisfying.”</div>
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The research was funded by the <a class="ext" href="http://www.nih.gov/" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #0077c3; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: bold; letter-spacing: 0.05em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">National Institutes of Health</a><span class="ext" style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: url(http://www.hsci.harvard.edu/sites/all/modules/extlink/extlink.png); background-origin: initial; background-position: 100% 50%; background-repeat: no-repeat no-repeat; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 12px; padding-top: 0px; vertical-align: baseline;"></span>, the <a class="ext" href="http://www.hhmi.org/" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #0077c3; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: bold; letter-spacing: 0.05em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">Howard Hughes Medical Institute</a><span class="ext" style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: url(http://www.hsci.harvard.edu/sites/all/modules/extlink/extlink.png); background-origin: initial; background-position: 100% 50%; background-repeat: no-repeat no-repeat; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 12px; padding-top: 0px; vertical-align: baseline;"></span>, the Stem Cell Cyclists of the <a class="ext" href="http://www.pmc.org/" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #0077c3; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: bold; letter-spacing: 0.05em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">Pan-Mass Challenge</a><span class="ext" style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: url(http://www.hsci.harvard.edu/sites/all/modules/extlink/extlink.png); background-origin: initial; background-position: 100% 50%; background-repeat: no-repeat no-repeat; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 12px; padding-top: 0px; vertical-align: baseline;"></span>, and the Patrick Carney Foundation.</div>
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Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-7296627463148736072013-09-13T13:24:00.002-04:002013-09-13T13:24:27.169-04:00<div dir="ltr" style="text-align: left;" trbidi="on">
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Ready to unlock stem cell mysteries</h1>
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The NanoCollege and blue cowboy boots are two of this researcher's passions</h5>
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Published 6:45 pm, Monday, March 25, 2013</h5>
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VIEW: <a href="http://www.timesunion.com/business/article/Ready-to-unlock-stem-cell-mysteries-4383257.php#" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: black; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">LARGER</a> <span class="lim" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 7px; margin-right: 7px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">|</span> <a href="http://www.timesunion.com/business/article/Ready-to-unlock-stem-cell-mysteries-4383257.php#" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: black; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">HIDE</a></div>
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Janet Paluh, associate professor of nanobioscience, points to cells on her computer screen in a lab at the College for Nanoscale Science on Thursday Dec. 20, 2012 in Albany, N.Y. (Lori Van Buren / Times Union)</div>
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margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline !important;">Share</span></span></a></span></span></span></div>
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<a href="http://www.timesunion.com/local/article/Driver-ticketed-after-fuel-truck-leaks-4811789.php" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #08478d; font-family: inherit; font-size: 14px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">Driver ticketed after fuel truck leaks</a></h4>
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<a href="http://www.timesunion.com/local/article/Climber-found-dead-at-Thacher-Park-4811562.php" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #08478d; font-family: inherit; font-size: 14px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">Climber found dead at Thacher Park</a></h4>
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<a href="http://www.timesunion.com/local/article/Town-of-Nassau-leader-urges-caution-4810655.php" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #08478d; font-family: inherit; font-size: 14px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">Town of Nassau leader urges caution</a></h4>
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<a href="http://www.timesunion.com/local/article/Field-is-big-win-for-UAlbany-coach-4810633.php" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #08478d; font-family: inherit; font-size: 14px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">Field is big win for UAlbany coach</a></h4>
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<i style="font-style: italic;">Albany</i></div>
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Embryonic stem cell researcher <a href="http://www.timesunion.com/?controllerName=search&action=search&channel=business&search=1&inlineLink=1&query=%22Janet+Paluh%22" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #08478d; font-family: inherit; font-size: 15px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">Janet Paluh</a> is an ex-California surfer girl who worked in the pits for a stock car rally race team and owns a head-turning shoe collection.</div>
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The associate professor of nanobioscience at the<a href="http://www.timesunion.com/?controllerName=search&action=search&channel=business&search=1&inlineLink=1&query=%22College+of+Nanoscale+Science+and+Engineering%22" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #08478d; font-family: inherit; font-size: 15px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">College of Nanoscale Science and Engineering</a>favors two-tone electric blue cowboy boots in the lab.</div>
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She changes the oil, does tune-ups and makes small engine repairs on her 1985 Saab 900 Turbo with 400,000 miles. She also works on her winter car, a 2002 Saab 9.5 Aero.</div>
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She brings to her work aspects of her mother (a former fashion model in New York City) and late father (a West Point graduate, Vietnam War veteran and lieutenant colonel).</div>
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What attracted Paluh to the NanoCollege at the University at Albany in 2006 after stints at Berkeley, Stanford and RPI was the opportunity to teach undergraduates and conduct research using cutting-edge technology in a world-class facility.</div>
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"Any researcher would die to be in this setting. It's like working in a toy store with every toy available," she said.</div>
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She grows 1,000 human pluripotent stem cells in a 200-micron thermoset plastic holder to the size of an orchid seed. She and her students seed the cells and grow and tweak them through nanoengineering so they can study how the cells interact and transform into complex 3-D cell structures. "The beauty of what we can do here is not just view pluripotent stem cells, but manipulate them and make complex 3-D cell structures for tissues and organ engineering," Paluh said.</div>
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With the help of a $1 million NYSTEM state grant to derive and study new human pluripotent stem cell lines, her research may one day provide the tools and point the way to prevention, diagnosis and treatment of cancer and developmental diseases.</div>
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The same lab equipment, remarkably precise and quite expensive, is used by other nanobioscience researchers. That sharing of resources creates random productive collaborations that yield unexpected insights across various areas of research.</div>
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"It sounds perhaps corny, but we're all thinking five, 10 or 20 years ahead and asking how what we're doing can benefit mankind," she said.</div>
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An Atlanta native who moved frequently with her five siblings, Paluh lived on military bases, including Fort Benjamin Harrison in Indiana. Army tanks served as her jungle gyms. She was a precocious tomboy who was gifted at math and science. Her dad taught her how to play chess at a young age, and she got so good that she could checkmate generals by the time she was a teenager.</div>
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She also grew up with horses and thought of pursuing veterinary medicine at <a href="http://www.timesunion.com/?controllerName=search&action=search&channel=business&search=1&inlineLink=1&query=%22Purdue+University%22" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #08478d; font-family: inherit; font-size: 15px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">Purdue University</a>, but a course in genetic engineering as a junior changed her career path.</div>
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"I had an amazing teacher who got me excited about the power of recombinant DNA," she said.</div>
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Paluh does her deepest thinking in the solitude of hiking, long-distance running and cycling.</div>
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The daily interaction with her students also feeds her creativity.</div>
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"Undergraduates ask very basic, almost naive questions that can be brilliant," she said. "My students help me from thinking too narrowly about nanobioscience and invite unexpected possibilities."</div>
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At times, Paluh feels homesick for her years in California's Bay Area, where she did her doctoral and postdoctoral work.</div>
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She spent a lot of time in San Francisco and shopped in the boutiques along bohemian Haight Street. The electric blue cowboy boots are an homage to Haight Street, as well as her mother's advice.</div>
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"A well-dressed woman," she often said, "is well-heeled."</div>
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Living among free spirits was also beneficial to her research.</div>
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"San Francisco helped me become a non-traditional thinker," she said. "I decided that I never wanted to run with the pack."</div>
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<i style="font-style: italic;"><a href="mailto:pgrondahl@timesunion.com" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #08478d; font-family: inherit; font-size: 15px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">pgrondahl@timesunion.com</a></i><i style="font-style: italic;"> </i><i style="font-style: italic;">•</i><i style="font-style: italic;"> </i><i style="font-style: italic;">518-454-5623</i><i style="font-style: italic;"> </i><i style="font-style: italic;">•</i><i style="font-style: italic;"> </i><i style="font-style: italic;">@PaulGrondahl</i></div>
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<b>Vitals</b></div>
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Janet Paluh, 53, of Malta.</div>
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Bachelor and master degrees in biochemistry, Purdue University. Ph.D. in cancer biology, Stanford University; and postdoctoral fellow University of California at Berkeley.</div>
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Single, no children.</div>
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Free time: Hiking, cycling, running in summer; skiing and snowboarding in winter.</div>
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To view a video of Janet Paluh, go to <a href="http://timesunion.com/" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #08478d; font-family: inherit; font-size: 15px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">http://timesunion.com</a>.</div>
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Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-47134332278559126012013-09-02T10:05:00.001-04:002013-09-02T10:05:48.946-04:00<div dir="ltr" style="text-align: left;" trbidi="on">
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<span lang="EN" style="color: #333333; font-family: Tahoma, sans-serif; font-size: 8pt; line-height: 15px;">Alison Fisk Urzan</span><span lang="EN" style="color: #333333; font-family: Tahoma, sans-serif; font-size: 8.5pt; line-height: 15px;"></span></div>
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<strong style="font-weight: bold; line-height: 22px;"><span style="color: black; line-height: 22px;">2013 </span></strong><b style="font-weight: bold; line-height: 22px;"><span style="color: black; line-height: 22px;"><img border="0" height="42" id="ecxMA2.1377783186" src="https://blu169.afx.ms/att/GetInline.aspx?messageid=44c42050-10c6-11e3-b783-002264c1d2c0&attindex=1&cp=-1&attdepth=1&imgsrc=cid%3aimage002.gif%4001CEA4B1.565068C0&cid=5e79c9bf76699c03&hm__login=brotherbob1228&hm__domain=hotmail.com&ip=10.15.228.8&d=d3540&mf=0&hm__ts=Mon%2c%2002%20Sep%202013%2014%3a04%3a39%20GMT&st=brotherbob1228&hm__ha=01_b6cd11565cf91293ce4e877a54a2d05b3a11d129be35d27eeef5b9caa591367a&oneredir=1" style="line-height: 22px;" width="46" /></span></b><span style="color: black; line-height: 22px;"></span></div>
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<b style="font-weight: bold; line-height: 22px;"><span style="color: black; font-family: Arial, sans-serif; font-size: 14pt; line-height: 26px;">5<sup style="line-height: 22px;">TH</sup> ANNUAL RALLY FOR ALI ! </span></b></div>
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<b style="font-weight: bold; line-height: 22px;"><span style="color: black; font-family: Arial, sans-serif; font-size: 24pt; line-height: 45px;">URGENT NEED FOR RALLY VOLUNTEERS !!</span></b><b style="font-weight: bold; line-height: 22px;"><span style="color: black; font-family: 'Comic Sans MS'; font-size: 24pt; line-height: 45px;"> </span></b></div>
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<span style="color: black; line-height: 22px;">As the time for our annual Rally for Ali event now draws very near, we urgently need all of Ali's friends that can possibly help, along with any others who wish to do so, to volunteer a little of their time to work in any way they can on her Rally. </span><span style="color: black; font-family: Arial, sans-serif; font-size: 10pt; line-height: 18px;"></span></div>
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<b style="font-weight: bold; line-height: 22px;"><span style="color: black; font-family: Arial, sans-serif; line-height: 22px;">In advance of the Rally</span></b><span style="color: black; font-family: Arial, sans-serif; line-height: 22px;"> we need help with putting up flyers, getting out other publicity and obtaining gift certificates<strong style="font-weight: bold; line-height: 22px;"><span style="font-family: Arial, sans-serif; line-height: 22px;">. </span></strong><strong style="font-weight: bold; line-height: 22px;"><span style="font-family: Arial, sans-serif; font-weight: normal; line-height: 22px;">We’d like to try to have as many of the gift certificates and raffle items by our last committee meeting. </span></strong></span><span style="color: black; font-family: Arial, sans-serif; font-size: 10pt; line-height: 18px;"></span></div>
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<strong style="font-weight: bold; line-height: 22px;"><span style="color: black; font-family: Arial, sans-serif; line-height: 22px;">At the Rally </span></strong><strong style="font-weight: bold; line-height: 22px;"><span style="color: black; font-family: Arial, sans-serif; font-weight: normal; line-height: 22px;">we will also need help </span></strong><span style="color: black; font-family: Arial, sans-serif; line-height: 22px;">with decorations, set up, ticket sales, T-shirt sales, etc.</span><strong style="font-weight: bold; line-height: 22px;"><span style="font-weight: normal; line-height: 22px;"></span></strong></div>
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<span style="color: black; font-family: Arial, sans-serif; line-height: 22px;">If anyone has or will have any donations collected and in your possession, please contact Mary DuBois at</span><span style="color: #1f497d; font-family: Arial, sans-serif; line-height: 22px;"></span><span style="color: black; font-family: Arial, sans-serif; line-height: 22px;"><a href="mailto:Duboisma@nycap.rr.com" style="color: blue; cursor: pointer; font-weight: inherit; line-height: 22px; text-decoration: underline;" title="mailto:Duboisma@nycap.rr.com">Duboisma@nycap.rr.com</a></span><span style="color: #1f497d; font-family: Arial, sans-serif; line-height: 22px;"> </span><span style="color: black; font-family: Arial, sans-serif; line-height: 22px;">or call her on her cell at 518-526-9888 by <b style="font-weight: bold; line-height: 22px;">September 9th</b> to let her know what you’ve collected with the item and value and if you can’t come to the last committee meeting, she will arrange for its collection.</span></div>
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<span style="color: black; font-family: Arial, sans-serif; line-height: 22px;">Our last full Committee Meeting will be held at our Chairman Wally Urzan’s home at 288 ½ 10<sup style="line-height: 18px;">th</sup> Street, Troy NY on Tuesday, <b style="font-weight: bold; line-height: 22px;">September 10<sup style="line-height: 18px;">th</sup> at 6 pm</b>. If you can’t attend but are still willing to volunteer in advance of the Rally or at the Rally, please let us know how you’d like to help. Volunteers will be coordinated by Mary Dubois <a href="mailto:Duboisma@nycap.rr.com" style="color: blue; cursor: pointer; font-weight: inherit; line-height: 22px; text-decoration: underline;" title="mailto:Duboisma@nycap.rr.com">Duboisma@nycap.rr.com</a> and Victoria Gettings <a href="mailto:Vgettings@RealtyUSA.com" style="color: blue; cursor: pointer; font-weight: inherit; line-height: 22px; text-decoration: underline;" title="mailto:Vgettings@RealtyUSA.com">Vgettings@RealtyUSA.com</a> </span></div>
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<span style="color: black; font-family: Arial, sans-serif; line-height: 22px;">The Rally will be held on Saturday, September 21, 2013 at Krause’s Grove in </span><span style="font-family: Arial, sans-serif; line-height: 22px;"><span style="color: black; line-height: 22px;">Halfmoon</span><span style="color: black; line-height: 22px;">, </span><span style="color: black; line-height: 22px;">NY</span><span style="color: black; line-height: 22px;">. </span></span><span style="color: black; line-height: 22px;"></span></div>
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<span style="color: black; font-family: Arial, sans-serif; line-height: 22px;">All donations raised in Ali’s memory will go to Harvard Stem Cell Institute in rigorous search of a CURE for diabetes.</span><span style="color: black; line-height: 22px;"></span></div>
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<span style="color: black; font-family: Arial, sans-serif; line-height: 22px;">The help and support of all who are able to volunteer in this very worthy Cause is deeply appreciated</span><span style="color: black; font-family: 'Comic Sans MS'; font-size: 10pt; line-height: 18px;">.</span><span style="color: black; line-height: 22px;"></span></div>
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<span style="color: black; font-family: Arial, sans-serif; font-size: 10pt; line-height: 18px;">GOD BLESS AND MUCH LOVE ~</span></div>
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<span style="color: black; font-family: Arial, sans-serif; font-size: 10pt; line-height: 18px;">THE FAMILY OF ALISON FISK URZAN </span><span style="color: black; font-family: Arial, sans-serif; font-size: 8pt; line-height: 15px;"><a href="mailto:Afisk10302@aol.com" style="color: blue; cursor: pointer; font-weight: inherit; line-height: 15px; text-decoration: underline;" title="mailto:Afisk10302@aol.com"><span style="font-size: 12pt; line-height: 22px;">Afisk10302@aol.com</span></a></span><span style="color: black; font-size: 10pt; line-height: 18px;"></span></div>
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<b style="font-weight: bold; line-height: 22px;"><span style="color: green; font-family: 'Comic Sans MS'; font-size: 22pt; line-height: 41px;"> 5th ANNUAL RALLY 4 ALI</span></b><span style="color: green; font-family: Arial, sans-serif; font-size: 22pt; line-height: 41px;"> </span></div>
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Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-20421809466899171882013-09-02T09:56:00.001-04:002013-09-02T09:56:48.297-04:00<div dir="ltr" style="text-align: left;" trbidi="on">
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ReNeuron's stem cell therapy wins orphan status</h1>
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WORLD NEWS | AUGUST 29, 2013</div>
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<img alt="ReNeuron's stem cell therapy wins orphan status" class="ArticleImage" id="ctl00_Content_NewsView1_ctl00_ctl00_ThumbnailBG" src="http://www.pharmatimes.com/Libraries/Healthcare/eye.sflb.ashx" style="border-bottom-width: 0px; border-left-width: 0px; border-right-width: 0px; border-top-width: 0px; float: right; margin-bottom: 10px; margin-left: 10px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;" title="ReNeuron's stem cell therapy wins orphan status" /></div>
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There was good news for ReNeuron this week as regulators on both sides of the Atlantic awarded its eye disease stem cell therapy orphan drug designation.</div>
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<a href="http://www.pharmatimes.com/Article/13-07-23/Stem_cell_firm_ReNeuron_raises_%c2%a333_million.aspx" id="ctl00_Content_NewsView1_ctl00_ctl00_RelatedLinks" style="color: #333333; display: block; margin-bottom: 5px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">Stem cell firm ReNeuron raises £33 million</a><a href="http://www.pharmatimes.com/Article/13-03-28/ReNeuron_signs_landmark_pact_to_advance_stem_cell_line.aspx" id="ctl00_Content_NewsView1_ctl00_ctl00_RelatedLinks1" style="color: #333333; display: block; margin-bottom: 5px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">ReNeuron signs 'landmark' pact to advance stem cell line</a><a href="http://www.pharmatimes.com/Article/12-05-17/ReNeuron_s_UK_stem-cell_trial_edges_towards_Phase_II.aspx" id="ctl00_Content_NewsView1_ctl00_ctl00_RelatedLinks2" style="color: #333333; display: block; margin-bottom: 5px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">ReNeuron’s UK stem-cell trial edges towards Phase II</a><a href="http:/" id="ctl00_Content_NewsView1_ctl00_ctl00_RelatedLinks3" style="color: #333333; display: block; margin-bottom: 5px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"></a><a href="http:/" id="ctl00_Content_NewsView1_ctl00_ctl00_RelatedLinks4" style="color: #333333; display: block; margin-bottom: 5px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"></a><a href="http:/" id="ctl00_Content_NewsView1_ctl00_ctl00_RelatedLinks5" style="color: #333333; display: block; margin-bottom: 5px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;"></a></div>
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Both the European Commission and US Food and Drug Administration have classed ReN003 an orphan drug for the treatment of retinitis pigmentosa, a group of hereditary progressive eye diseases that damage retinal cells and cause sight loss, which affect about four in 10,000 people in the EU and US. </div>
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This is very good news for ReNeuron, given that treatments with this designation benefit from significant commercial and regulatory advantages such as market exclusivity for 10 years from approval in the disease concerned, against other treatments offering no greater therapeutic advantage.</div>
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ReNeuron chief executive Michael Hunt said he is "delighted" with the move. </div>
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“Orphan status diseases are an increasing area of therapeutic and commercial focus by the mainstream pharmaceutical industry due to the distinct regulatory and market exclusivity advantages that Orphan Drug Designation confers". </div>
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“This fact bodes well for the commercial potential of our ReN003 therapy," he noted.</div>
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The UK group said it is expecting to file applications for an initial Phase I/II clinical trial with ReN003 in the UK and the US in the middle part of 2014.</div>
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Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-52788834958153475732013-07-30T08:30:00.001-04:002013-07-30T08:30:53.946-04:00<div dir="ltr" style="text-align: left;" trbidi="on">
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Human stem cell-derived hepatocytes regenerate liver function</h1>
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Published: Sunday, July 28, 2013 - 13:02 <span class="terms" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">in <a href="http://esciencenews.com/topics/biology.nature" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #096fb2; font-family: inherit; font-size: 12px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: none; outline-width: initial; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">Biology & Nature</a></span></div>
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Researchers have generated functional hepatocytes from human stem cells, transplanted them into mice with acute liver injury, and shown the ability of these stem-cell derived human liver cells to function normally and increase survival of the treated animals. This promising advance in the development of cell-based therapies to treat liver failure resulting from injury or disease relied on the development of scalable, reproducible methods to produce stem cell-derived hepatocytes in bioreactors, as described in an article in <em style="background-attachment: initial; background-clip: initial; background-color: #ffffcc; background-image: initial; background-origin: initial; background-position: initial initial; background-repeat: initial initial; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 13px; font-style: italic; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Stem Cells and Development</em>. Massoud Vosough and coauthors demonstrate a large-scale, integrated manufacturing strategy for generating functional hepatocytes in a single suspension culture grown in a scalable stirred bioreactor. In the article "Generation of Functional Hepatocyte-Like Cells from Human Pluripotent Stem Cells in a Scalable Suspension Culture" the authors describe the method used for scale-up, differentiation of the pluripotent stem cells into liver cells, and characterization and purification of the hepatocytes based on their physiological properties and the expression of liver cell biomarkers.</div>
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David C. Hay, MRC Centre for Regenerative Medicine, University of Edinburgh, U.K., comments on the importance of Vosough et al.'s contribution to the scientific literature in his editorial in <em style="background-attachment: initial; background-clip: initial; background-color: #ffffcc; background-image: initial; background-origin: initial; background-position: initial initial; background-repeat: initial initial; border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; font-family: inherit; font-size: 13px; font-style: italic; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;">Stem Cells and Development</em> entitled "Rapid and Scalable Human Stem Cell Differentiation: Now in 3D." The researchers "developed a system for mass manufacture of stem cell derived hepatocytes in numbers that would be useful for clinical application," creating possibilities for future "immune matched cell based therapies," says Hay. Such approaches could be used to correct mutated genes in stem cell populations prior to differentiation and transplantation, he adds.</div>
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"The elephant in the room for stem cell therapy rarely even acknowledged let alone addressed in the literature is that of scalable production of cells for translational application," says Editor-in-Chief Graham C. Parker, PhD, research professor, Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine. "Baharvand's groups' landmark publication not only demonstrates but exquisitely describes the methodology required to scale up stem cell populations for clinical application with a rigor to satisfy necessary manufacturing standards."</div>
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Source: <a href="http://www.liebertpub.com/" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #096fb2; font-family: inherit; font-size: 18px; font-style: inherit; font-weight: inherit; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; outline-color: initial; outline-style: none; outline-width: initial; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none; vertical-align: baseline;">Mary Ann Liebert, Inc./Genetic Engineering News</a></h2>
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Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-4717644562724878952013-06-30T17:01:00.001-04:002013-06-30T17:01:21.236-04:00ABC News - Stem Cell Therapy Becomes More Widely Available<iframe allowfullscreen="" frameborder="0" height="270" src="//www.youtube.com/embed/7qNz37cfWj0" width="480"></iframe>Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-64877233487153673252013-06-28T13:49:00.001-04:002013-06-28T13:49:32.844-04:00<div dir="ltr" style="text-align: left;" trbidi="on">
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Tokyo OKs world’s first IPS stem cell trial</h1>
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June 28 2013 at 03:30pm <br style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;" />By Kyoko Hasegawa</div>
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A human embryonic stem cell line derived at Stanford University is seen in this handout photo released to Reuters by the California Institute for Regenerative Medicine.</div>
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Tokyo - Japan has given the green light to the world's first clinical trial using stem cells harvested from a patient's own body, officials said on Thursday, testing a treatment that may offer hope to millions of people robbed of their sight.</div>
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A government committee approved proposals for tests aimed at treating age-related macular degeneration (AMD), a common medical condition that causes blindness in older people, using “induced Pluripotent Stem (iPS) cells”, a health ministry official said.</div>
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The trial treatment will try to create retinal cells that can be transplanted into the eyes of patients suffering from AMD, replacing the damaged part of the eye.</div>
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AMD, a condition that is incurable at present, affects mostly middle-aged and older people and can lead to blindness. It afflicts around 700 000 people in Japan alone.</div>
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Stem cell research is a pioneering field that has excited many in the scientific community with the potential they believe it offers.</div>
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A China-based research group on Wednesday said they were hoping for regulatory approval to test stemcell therapy on spinal cord injuries they believe can help immobile people walk again.</div>
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Stem cells are infant cells that can develop into any part of the body.</div>
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Until the discovery of iPS cells several years ago, the only way to obtain stem cells was to harvest them from human embryos.</div>
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This is controversial because it requires the destruction of the embryo, a process to which religious conservatives, among others, object.</div>
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Groundbreaking work done in 2006 by Shinya Yamanaka at Kyoto University, a Nobel Laureate in medicine last year, succeeded in generating stem cells from adult skin tissue.</div>
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Like embryonic stem cells, iPS cells are also capable of developing into any cell in the body, but crucially their source material is readily available.</div>
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Following the government approval, the Riken Centre for Developmental Biology will start the world's first clinical trial using iPS cells as soon as next summer, a Riken spokesperson said.</div>
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Riken will recruit six patients suffering from AMD, all aged at least 50 years, and take cells from their skin.</div>
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These cells will be genetically reprogrammed to become iPS cells. The infant cells will then be nudged in the direction of developing into retina cells.</div>
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Once a network of retina cells has been developed - a process that could take around 10 months - this can be transplanted into the patient's eye, the spokesperson said.</div>
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Patients will be monitored over the next four years to determine how well the implants have performed, whether the body has accepted them and if they have become cancerous.</div>
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“Because no one in the world has used iPS cells in a clinical trial, what we are doing will set the standard,” research leader Masayo Takahashi told the Mainichi, a daily paper. “It's a daunting prospect, but one that brings joy.”</div>
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She said she expects that patients in the initial trial will see only a very modest improvement in their sight.</div>
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“We don't want people to have excessive expectations,” she said.</div>
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Kanji Takahashi, chief ophthalmologist at Kansai Medical University Hirokata hospital, told AFP the trial was a positive step, but not a done deal.</div>
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He said current treatment regimes include monthly drug injections directly into the eyes of AMD sufferers, at a cost of 150 000-170 000 yen per injection.</div>
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“Improving the eyesight of AMD patients is a difficult task, and what's important is whether transplanting cells improves vision,” he said.</div>
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“The trial is a hope for AMD patients, but it will probably take years before the new treatment will actually contribute to improving the vision of many people.” - Sapa-AFP</div>
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Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-4783791342731103722013-06-26T11:08:00.001-04:002013-06-26T11:08:55.314-04:00<div dir="ltr" style="text-align: left;" trbidi="on">
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Hong Kong stem-cell trial gives spinal patients hope</h1>
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<li class="date-and-time last" style="-webkit-box-sizing: border-box; display: inline; float: left; list-style-image: none; list-style-type: none; margin-left: 0px; padding-left: 7px; padding-right: 0px; vertical-align: middle; white-space: nowrap;"><span class="datestamp" style="-webkit-box-sizing: border-box;">JUNE 26, 2013</span> <span class="timestamp" style="-webkit-box-sizing: border-box;">11:48PM</span></li>
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<span class="caption-text" style="-webkit-box-sizing: border-box;">A stem-cell trial in Hong Kong has given hope for spinal patients. </span><span class="image-source" style="-webkit-box-sizing: border-box;"><em style="-webkit-box-sizing: border-box;">Source:</em> Supplied</span></div>
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<strong style="-webkit-box-sizing: border-box; font-weight: bold;">A RESEARCHER into severe spinal cord injuries said trials for stem-cell therapy showed groundbreaking results in helping immobile patients walk again.</strong></div>
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After progress in a second round of tests using stem cells to regrow nerve fibres, the China Spinal Cord Injury Network (ChinaSCINet) has applied for regulatory approval in China for a third and final phase, which it hopes to start in the autumn.</div>
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"This will convince the doctors of the world that they do not need to tell patients 'you will never walk again'," US-based doctor Wise Young, chief executive officer of ChinaSCINet, said.</div>
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He said that 15 out of 20 patients in the Chinese city of Kunming, who received umbilical cord blood cell transplants and intensive walking therapy, were on average able to walk with minimal assistance seven years after complete spinal cord injury.</div>
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"It's the first time in human history that we can see the regeneration of the spinal cord," Dr Young said.</div>
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The treatment involves injecting umbilical cord blood mononuclear cells into patients' damaged spines to help regenerate nerves, while lithium is used to promote the growth of the nerve fibres.</div>
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Each component of the combination therapy will be tested in the third phase, which Dr Young said would involve 120 patients in China and another 120 across India, Norway and the United States.</div>
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"If the phase three trial is successful, we should have achieved worldwide regulatory approval by the beginning to the middle of 2015," he said.</div>
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ChinaSCINet, a non-profit organisation that calls itself the world's largest clinical trial network for spinal cord therapies, was established in Hong Kong in 2005.</div>
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"Hong Kong is going to be way ahead of all the other countries if the spinal cord injury trial turns out to be positive," Dr Young said.</div>
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"That means Hong Kong will be the centre for stem-cell therapies."</div>
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Dr Young also said China is investing heavily into stem-cell research, while the technology remains highly controversial in the United States because of the anti-abortion camp's concerns about cells derived from human embryos.</div>
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Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-92082249115236995712013-06-26T10:46:00.001-04:002013-06-26T10:46:51.382-04:00<div dir="ltr" style="text-align: left;" trbidi="on">
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Stem Cells Market is Expected to Reach USD 119.51 Billion Globally in 2018: Transparency Market Research</h1>
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By <a href="http://www.sacbee.com/search_results/?sf_pubsys_story_byline=Transparency%20Market%20Research&link_location=top" style="color: #024a82; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;" title="Read more articles by Transparency Market Research"><span>Transparency Market Research</span></a></div>
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<div class="published" style="padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;" title="2013-06-25T02:41:30-0700">
Published: Tuesday, Jun. 25, 2013 - 2:41 am</div>
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<span class="dateline">ALBANY, <a class=" lingo_link lingo_link_hidden" href="http://topics.sacbee.com/New+York/" rel="nofollow" style="border-bottom-color: initial; border-bottom-style: none; border-bottom-width: 1px; border-color: initial; border-left-style: none; border-right-style: none; border-top-style: none; border-width: initial; color: black; cursor: pointer; display: inline; font-family: Georgia, 'Times New Roman', Times, serif; font-size: 15px; font-style: normal; font-weight: normal; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;">New York,</a> June 25, 2013 --</span>/PRNewswire/ --</div>
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According to a new market report published by Transparency Market Research (<a href="http://www.transparencymarketresearch.com/" style="color: #024a82; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;">http://www.transparencymarketresearch.com</a>)<b>"</b><b><a class=" lingo_link lingo_link_hidden" href="http://topics.sacbee.com/Stem+Cells/" rel="nofollow" style="border-bottom-color: initial; border-bottom-style: none; border-bottom-width: 1px; border-color: initial; border-left-style: none; border-right-style: none; border-top-style: none; border-width: initial; color: black; cursor: pointer; display: inline; font-family: Georgia, 'Times New Roman', Times, serif; font-size: 15px; font-style: normal; font-weight: bold; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;">Stem Cells</a> Market (Adult, Human Embryonic , Induced Pluripotent, Rat-Neural, Umbilical Cord, Cell Production, Cell Acquisition, Expansion, Sub-Culture)</b><b>-</b> <b>Global Industry Analysis, Size, Share, Growth, Trends and Forecast</b><b>,</b> <b>2012</b> <b>-</b> <b>2018</b><b>,</b><b>"</b> the market for <a class=" lingo_link lingo_link_hidden" href="http://topics.sacbee.com/Stem+Cells/" rel="nofollow" style="border-bottom-color: initial; border-bottom-style: none; border-bottom-width: 1px; border-color: initial; border-left-style: none; border-right-style: none; border-top-style: none; border-width: initial; color: black; cursor: pointer; display: inline; font-family: Georgia, 'Times New Roman', Times, serif; font-size: 15px; font-style: normal; font-weight: normal; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;">stem cells</a> was valued at USD 26.23 billion in 2011 and is expected to reach an estimated value of USD 119.51 billion in 2018, growing at a CAGR of 24.2% from 2012 to 2018.</div>
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<b>Browse the full report at </b><a href="http://www.transparencymarketresearch.com/stem-cells-market.html" style="color: #024a82; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;"><b>http://www.transparencymarketresearch.com/stem-cells-market.html</b></a></div>
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The market growth is majorly attributed to therapeutic research activities led by government support worldwide owing to the growing number of patients with chronic diseases across the globe. In addition, rising awareness of regenerative treatment options and growing importance of stem cell banking services are also fostering the growth of the market. Apart from these, development of medical tourism hubs in <a class=" lingo_link" href="http://topics.sacbee.com/developing+nations/" rel="nofollow" style="border-bottom-color: initial; border-bottom-style: dotted; border-bottom-width: 1px; color: #024a82; cursor: pointer; display: inline; font-family: Georgia, 'Times New Roman', Times, serif; font-size: 15px; font-style: normal; font-weight: normal; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;">developing nations</a> such as India and China and in turn migration of patients from developed nations such as the U.S., and Europe for quality treatment at significantly lower prices will also serve the market as a driver especially for the Asian <a class=" lingo_link lingo_link_hidden" href="http://topics.sacbee.com/Stem+Cells/" rel="nofollow" style="border-bottom-color: initial; border-bottom-style: none; border-bottom-width: 1px; border-color: initial; border-left-style: none; border-right-style: none; border-top-style: none; border-width: initial; color: black; cursor: pointer; display: inline; font-family: Georgia, 'Times New Roman', Times, serif; font-size: 15px; font-style: normal; font-weight: normal; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;">stem cells</a> market.</div>
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<a class=" lingo_link lingo_link_hidden" href="http://topics.sacbee.com/Stem+Cells/" rel="nofollow" style="border-bottom-color: initial; border-bottom-style: none; border-bottom-width: 1px; border-color: initial; border-left-style: none; border-right-style: none; border-top-style: none; border-width: initial; color: black; cursor: pointer; display: inline; font-family: Georgia, 'Times New Roman', Times, serif; font-size: 15px; font-style: normal; font-weight: normal; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;">Stem cells</a> market will be driven by rising proportion of patients with neurological and other chronic conditions and rising disposable incomes of patients induced by economic growth of Asian regions in the next five years In addition, increasing dependence on <a class=" lingo_link lingo_link_hidden" href="http://topics.sacbee.com/Stem+Cells/" rel="nofollow" style="border-bottom-color: initial; border-bottom-style: none; border-bottom-width: 1px; border-color: initial; border-left-style: none; border-right-style: none; border-top-style: none; border-width: initial; color: black; cursor: pointer; display: inline; font-family: Georgia, 'Times New Roman', Times, serif; font-size: 15px; font-style: normal; font-weight: normal; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;">stem cells</a> for <a class=" lingo_link" href="http://topics.sacbee.com/Drug+Discovery/" rel="nofollow" style="border-bottom-color: initial; border-bottom-style: dotted; border-bottom-width: 1px; color: #024a82; cursor: pointer; display: inline; font-family: Georgia, 'Times New Roman', Times, serif; font-size: 15px; font-style: normal; font-weight: normal; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;">drug discovery</a>and screening will boost the growth of the market in future. Increased outsourcing of contract research and clinical trials to developing Asian regions will further encourage growth of the <a class=" lingo_link lingo_link_hidden" href="http://topics.sacbee.com/Stem+Cells/" rel="nofollow" style="border-bottom-color: initial; border-bottom-style: none; border-bottom-width: 1px; border-color: initial; border-left-style: none; border-right-style: none; border-top-style: none; border-width: initial; color: black; cursor: pointer; display: inline; font-family: Georgia, 'Times New Roman', Times, serif; font-size: 15px; font-style: normal; font-weight: normal; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;">stem cells</a> market.</div>
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<a class=" lingo_link lingo_link_hidden" href="http://topics.sacbee.com/Adult+Stem+Cells/" rel="nofollow" style="border-bottom-color: initial; border-bottom-style: none; border-bottom-width: 1px; border-color: initial; border-left-style: none; border-right-style: none; border-top-style: none; border-width: initial; color: black; cursor: pointer; display: inline; font-family: Georgia, 'Times New Roman', Times, serif; font-size: 15px; font-style: normal; font-weight: normal; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;">Adult stem cells</a> held majority share of the overall <a class=" lingo_link lingo_link_hidden" href="http://topics.sacbee.com/Stem+Cells/" rel="nofollow" style="border-bottom-color: initial; border-bottom-style: none; border-bottom-width: 1px; border-color: initial; border-left-style: none; border-right-style: none; border-top-style: none; border-width: initial; color: black; cursor: pointer; display: inline; font-family: Georgia, 'Times New Roman', Times, serif; font-size: 15px; font-style: normal; font-weight: normal; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;">stem cells</a> market in 2011 at over 80%. This is due to less laborious procedure of harvesting, and less probability of contamination during expansion and sub-culture of <a class=" lingo_link lingo_link_hidden" href="http://topics.sacbee.com/Adult+Stem+Cells/" rel="nofollow" style="border-bottom-color: initial; border-bottom-style: none; border-bottom-width: 1px; border-color: initial; border-left-style: none; border-right-style: none; border-top-style: none; border-width: initial; color: black; cursor: pointer; display: inline; font-family: Georgia, 'Times New Roman', Times, serif; font-size: 15px; font-style: normal; font-weight: normal; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;">adult stem cells.</a> However, fewer post-transplant complications and lesser risk of graft vs. host reaction from the recently introduced induced pluripotent <a class=" lingo_link lingo_link_hidden" href="http://topics.sacbee.com/Stem+Cells/" rel="nofollow" style="border-bottom-color: initial; border-bottom-style: none; border-bottom-width: 1px; border-color: initial; border-left-style: none; border-right-style: none; border-top-style: none; border-width: initial; color: black; cursor: pointer; display: inline; font-family: Georgia, 'Times New Roman', Times, serif; font-size: 15px; font-style: normal; font-weight: normal; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;">stem cells</a> will lead to its rapid inclusion in research activities and help the global induced pluripotent <a class=" lingo_link lingo_link_hidden" href="http://topics.sacbee.com/Stem+Cells/" rel="nofollow" style="border-bottom-color: initial; border-bottom-style: none; border-bottom-width: 1px; border-color: initial; border-left-style: none; border-right-style: none; border-top-style: none; border-width: initial; color: black; cursor: pointer; display: inline; font-family: Georgia, 'Times New Roman', Times, serif; font-size: 15px; font-style: normal; font-weight: normal; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;">stem cells</a> market to grow at a relatively faster CAGR during the forecast period.</div>
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Regenerative medicine dominated the <a class=" lingo_link lingo_link_hidden" href="http://topics.sacbee.com/Stem+Cells/" rel="nofollow" style="border-bottom-color: initial; border-bottom-style: none; border-bottom-width: 1px; border-color: initial; border-left-style: none; border-right-style: none; border-top-style: none; border-width: initial; color: black; cursor: pointer; display: inline; font-family: Georgia, 'Times New Roman', Times, serif; font-size: 15px; font-style: normal; font-weight: normal; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;">stem cells</a> market by applications in 2011, and is expected to maintain its leading position till 2018. Considerable research activities and the resultant developed therapies in neurology will drive the <a class=" lingo_link lingo_link_hidden" href="http://topics.sacbee.com/Stem+Cells/" rel="nofollow" style="border-bottom-color: initial; border-bottom-style: none; border-bottom-width: 1px; border-color: initial; border-left-style: none; border-right-style: none; border-top-style: none; border-width: initial; color: black; cursor: pointer; display: inline; font-family: Georgia, 'Times New Roman', Times, serif; font-size: 15px; font-style: normal; font-weight: normal; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;">stem cells</a> market in the forecast period.</div>
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North America was the market leader of the total <a class=" lingo_link lingo_link_hidden" href="http://topics.sacbee.com/Stem+Cells/" rel="nofollow" style="border-bottom-color: initial; border-bottom-style: none; border-bottom-width: 1px; border-color: initial; border-left-style: none; border-right-style: none; border-top-style: none; border-width: initial; color: black; cursor: pointer; display: inline; font-family: Georgia, 'Times New Roman', Times, serif; font-size: 15px; font-style: normal; font-weight: normal; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;">stem cells</a> market in 2011 and is expected to maintain its leading position till 2018. North American market is a center for <a class=" lingo_link lingo_link_hidden" href="http://topics.sacbee.com/Stem+Cells/" rel="nofollow" style="border-bottom-color: initial; border-bottom-style: none; border-bottom-width: 1px; border-color: initial; border-left-style: none; border-right-style: none; border-top-style: none; border-width: initial; color: black; cursor: pointer; display: inline; font-family: Georgia, 'Times New Roman', Times, serif; font-size: 15px; font-style: normal; font-weight: normal; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;">stem cells</a> research owing to greater support offered by federal government, and higher affordability of treatment in the region. High prevalence of chronic diseases in the region and support in terms of funding from government and private organizations is driving the European <a class=" lingo_link lingo_link_hidden" href="http://topics.sacbee.com/Stem+Cells/" rel="nofollow" style="border-bottom-color: initial; border-bottom-style: none; border-bottom-width: 1px; border-color: initial; border-left-style: none; border-right-style: none; border-top-style: none; border-width: initial; color: black; cursor: pointer; display: inline; font-family: Georgia, 'Times New Roman', Times, serif; font-size: 15px; font-style: normal; font-weight: normal; outline-color: initial; outline-style: initial; outline-width: 0px; text-decoration: none;">stem cells</a> market.</div>
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The key players in stem cell research and technology include Advanced Cell Technology Inc., Stem Cell Technologies Inc., Cellular Engineering Technologies Inc., BioTime Inc., and Cellartis Ab among others.</div>
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Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-85989529320007962802013-06-21T18:41:00.001-04:002013-06-21T18:41:26.299-04:00Stem Cells Provide Novel Technique To Heal Wounds, Regenerate Cells And Prevent Scarring : Science/Tech : Medical Daily<a href="http://www.medicaldaily.com/articles/16706/20130620/skin-regeneration-wound-healing-scarring-cell-death-stem-cell-wounds.htm#.UcTWiCXYHHU.blogger">Stem Cells Provide Novel Technique To Heal Wounds, Regenerate Cells And Prevent Scarring : Science/Tech : Medical Daily</a>Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-30146052709849028772013-06-14T16:17:00.001-04:002013-06-14T16:17:30.299-04:00<div dir="ltr" style="text-align: left;" trbidi="on">
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Now, bank your stem cells for future use</h1>
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(The cells are presumably…)</div>
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<div style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #404040; font-family: Arial; font-size: 13px; line-height: 18px; margin-bottom: 15px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">
<span style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #404040; font-family: Arial; font-size: 13px; line-height: 18px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">WASHINGTON: With stem-cell therapies poised to become the next big thing in medical treatments, companies in the US are offering people a unique chance to bank their <a href="http://economictimes.indiatimes.com/topic/stem%20cells" style="border-bottom-width: 0px; border-color: initial; border-left-width: 0px; border-right-width: 0px; border-style: initial; border-top-width: 0px; color: #336797; font-family: Arial; font-size: 13px; font-weight: normal; line-height: 18px; margin-bottom: 10px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-decoration: none;">stem cells</a> for use in future.</span></div>
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It is believed that storing stem cells will come in handy in future when advance treatments are available. There will be stem cells ready to go that came from the patient's own body, eliminating the issue of rejection of donor cells.</div>
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Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com1tag:blogger.com,1999:blog-5151869116317538590.post-42495835185826016492013-05-29T12:54:00.001-04:002013-05-29T12:54:55.529-04:00Alan Trounson, California's Dr. Stem Cell<a href="http://www.latimes.com/news/opinion/commentary/la-oe-0529-morrison-trounson-20130529,0,7837846.column">Alan Trounson, California's Dr. Stem Cell</a>Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com1tag:blogger.com,1999:blog-5151869116317538590.post-61169670874950280012013-05-29T12:53:00.001-04:002013-05-29T12:53:03.273-04:00Stem cell trial offers stroke breakthrough hope<a href="http://articles.timesofindia.indiatimes.com/2013-05-28/science/39578686_1_stroke-patients-southern-general-hospital-antecubital-vein">Stem cell trial offers stroke breakthrough hope</a>Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-32880739624180559982013-05-29T12:52:00.001-04:002013-05-29T12:52:18.331-04:00First-ever successful stem cell transplant in Vietnam - Xinhua | English.news.cn<a href="http://news.xinhuanet.com/english/sci/2013-05/28/c_132413915.htm">First-ever successful stem cell transplant in Vietnam - Xinhua | English.news.cn</a>Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-81874014750723282902013-05-11T12:39:00.001-04:002013-05-11T12:39:56.850-04:00<div dir="ltr" style="text-align: left;" trbidi="on">
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Stem cell transplant restores memory, learning in mice</h1>
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<span style="font-size: 8pt;">By David Tenenbaum • ProHealth.com • May 11, 2013</span><br /><table cellpadding="0" cellspacing="0" style="background-color: #e9f2fa; margin-bottom: 5px; padding-bottom: 7px; padding-left: 7px; padding-right: 7px; padding-top: 7px; width: 540px;"><tbody>
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<i><img align="left" alt="" height="148" hspace="5" src="http://www.sxc.hu/pic/l/l/lo/lockstockb/977582_99611386.jpg" vspace="5" width="200" />Reprinted with kind permission of </i><a href="http://www.news.wisc.edu/21698" style="color: #006296; text-decoration: none;" target="_blank"><i>University of Wisconsin-Madison News</i></a></div>
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By David Tenenbaum</div>
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Apr. 21, 2013 — For the first time, human embryonic stem cells have been transformed into nerve cells that helped mice regain the ability to learn and remember.</div>
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A study at the University of Wisconsin-Madison is the first to show that human stem cells can successfully implant themselves in the brain and then heal neurological deficits, says senior author Su-Chun Zhang, a professor of neuroscience and neurology.</div>
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Once inside the mouse brain, the implanted stem cells formed two common, vital types of neurons, which communicate with the chemicals GABA or acetylcholine. "These two neuron types are involved in many kinds of human behavior, emotions, learning, memory, addiction and many other psychiatric issues," says Zhang.</div>
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The human embryonic stem cells were cultured in the lab, using chemicals that are known to promote development into nerve cells -- a field that Zhang has helped pioneer for 15 years. The mice were a special strain that do not reject transplants from other species.</div>
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After the transplant, the mice scored significantly better on common tests of learning and memory in mice. For example, they were more adept in the water maze test, which challenged them to remember the location of a hidden platform in a pool.</div>
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The study began with deliberate damage to a part of the brain that is involved in learning and memory.</div>
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Three measures were critical to success, says Zhang: location, timing and purity. "Developing brain cells get their signals from the tissue that they reside in, and the location in the brain we chose directed these cells to form both GABA and cholinergic neurons."</div>
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The initial destruction was in an area called the medial septum, which connects to the hippocampus by GABA and cholinergic neurons. "This circuitry is fundamental to our ability to learn and remember," says Zhang.</div>
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The transplanted cells, however, were placed in the hippocampus -- a vital memory center -- at the other end of those memory circuits. After the transferred cells were implanted, in response to chemical directions from the brain, they started to specialize and connect to the appropriate cells in the hippocampus.</div>
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The process is akin to removing a section of telephone cable, Zhang says. If you can find the correct route, you could wire the replacement from either end.</div>
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For the study, published in the current issue of Nature Biotechnology, Zhang and first author Yan Liu, a postdoctoral associate at the Waisman Center on campus, chemically directed the human embryonic stem cells to begin differentiation into neural cells, and then injected those intermediate cells. Ushering the cells through partial specialization prevented the formation of unwanted cell types in the mice.</div>
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Ensuring that nearly all of the transplanted cells became neural cells was critical, Zhang says. "That means you are able to predict what the progeny will be, and for any future use in therapy, you reduce the chance of injecting stem cells that could form tumors. In many other transplant experiments, injecting early progenitor cells resulted in masses of cells -- tumors. This didn't happen in our case because the transplanted cells are pure and committed to a particular fate so that they do not generate anything else. We need to be sure we do not inject the seeds of cancer."</div>
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Brain repair through cell replacement is a Holy Grail of stem cell transplant, and the two cell types are both critical to brain function, Zhang says. "Cholinergic neurons are involved in Alzheimer's and Down syndrome, but GABA neurons are involved in many additional disorders, including schizophrenia, epilepsy, depression and addiction."</div>
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Though tantalizing, stem-cell therapy is unlikely to be the immediate benefit. Zhang notes that "for many psychiatric disorders, you don't know which part of the brain has gone wrong." The new study, he says, is more likely to see immediate application in creating models for drug screening and discovery.</div>
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<b style="font-size: 10pt;">Reference</b>:</div>
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Yan Liu, Jason P Weick, Huisheng Liu, Robert Krencik, Xiaoqing Zhang, Lixiang Ma, Guo-min Zhou, Melvin Ayala, Su-Chun Zhang. Medial ganglionic eminence–like cells derived from human embryonic stem cells correct learning and memory deficits. <a href="http://www.ncbi.nlm.nih.gov/pubmed/23604284" style="color: #006296; text-decoration: none;" target="_blank">Nature Biotechnology</a>, 2013; DOI: 10.1038/nbt.2565</div>
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Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-76624130283034807092013-05-09T11:58:00.002-04:002013-05-09T11:58:06.087-04:00<div dir="ltr" style="text-align: left;" trbidi="on">
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Jilin student makes his second stem cell donation to ailing man</h2>
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Updated: 2013-05-09 08:06</h5>
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By Ou Hailin in Beijing and Han Junhong in Changchun (China Daily)</h3>
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<span><strong><span style="font-size: xx-small;">Wang Yuanxiang in Changchun, Jilin province, donates blood stem cells for a 37-year-old leukemia patient on Monday. Wang, a 24-year-old student at the Jilin Institute of Physical Education, has been a regular blood donor for six years. Sheng Xuesong / for China Daily</span></strong></span></div>
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Wang Yuanxiang donated his blood stem cells for a leukemia patient about 1,000 km away on Monday.</div>
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It is his second donation in three years to the same patient.</div>
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Wang, a 24-year-old college student at Jilin Institute of Physical Education in Northeast China's Jilin province, has been a regular blood donor for six years.</div>
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Encouraged by a cousin who is a doctor, Wang had made a habit of donating blood once every six months.</div>
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It was his donations of blood that has led to Wang's contact with the China Marrow Donor Program and later his donation of the life-giving cells.</div>
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"I was on a blood collection bus when a nurse asked me whether I want to be a marrow donor," Wang said.</div>
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"It was 2009, and I had seen basketball star Yao Ming being a marrow donor on TV. I signed up for the program because I believe either donation could help someone."</div>
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Two years later, Wang was told he was a match for a man dying of leukemia.</div>
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"When I informed (Wang) and asked whether he still wanted to donate, he said, 'I keep my word,' " said Yu Li, a staff member at the Jilin branch of the China Marrow Donor Program, which is under the Red Cross Society of China.</div>
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Yu had also asked the young man, then a 22-year-old junior, to inform his family and university about his donation. It was while school was in session, and once the matching process started, the recipient will shoulder all the costs involved, which could be massive and yet in vain if the donor gives up halfway through the process.</div>
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But Wang did not tell anyone, a strategy he abandoned for his second donation.</div>
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It took him 10 days away from school to complete the donation process, which included the physical examination, hospital admission and the collection of the stem cells.</div>
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When he returned from the hospital, however, Wang was nearly punished by the school for his absence from class, until a thank-you letter from the recipient came to his rescue and helped him explain everything.</div>
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This March, Wang was told that the patient who had received his blood stem cells needed a second marrow transplant, and he was the only match that the CMDP could find.</div>
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Like the first time, Wang did not hesitate to say yes.</div>
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"I told my family and my doctor cousin about the donation. At first they didn't agree. But I insisted that if I did not donate this time, then my first donation would be meaningless," Wang said.</div>
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"And I told them, 'I am a man now who can take the responsibility for what I have done,' " he said. He finally persuaded his family to allow his second donation.</div>
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The process of his second donation on Monday was shorter than the first, since first-time donors have to take a drug for six days to stimulate the formation of new blood cells.</div>
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"You don't have to be anesthetized," Wang referring to the collection of the stem cells from the blood.</div>
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"The doctor hooks you up to a machine that extracts the stem cells from your blood and returns all the rest of your blood to your body.</div>
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"The only thing that troubled me was that I had to stay in the same position for three hours," Wang said.</div>
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Contact the writers at ouhailin@chinadaily.com.cn and hanjunhong@chinadaily.com.cn</div>
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(China Daily 05/09/2013 page4)</div>
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Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-58638824523887900452013-05-07T13:51:00.001-04:002013-05-07T13:51:27.898-04:00<div dir="ltr" style="text-align: left;" trbidi="on">
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Stem cell research provides hope for epilepsy cure</h1>
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By <a ach="" achh="" class="userlink" href="http://www.digitaljournal.com/user/16559" pg="5" style="color: #555555; text-decoration: underline !important;">Kent Mao</a><div class="p" style="padding-bottom: 5px; padding-left: 1px; padding-right: 1px; padding-top: 5px;">
<abbr title="May 6, 2013 at 4:12PM EST">May 6, 2013</abbr> - 21 hours ago in <a class="department" href="http://www.digitaljournal.com/news/Health" style="color: #3366bb;">Health</a></div>
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Researchers from UC San Francisco have discovered a way to reverse severe forms of epilepsy in mice with stem cells, providing a new sense of hope for patients who suffer from the seizure-inducing disorder.<div style="padding-bottom: 15px;">
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Published earlier this month in <a href="http://www.nature.com/neuro/index.html" style="color: #3366bb;" target="_blank">Nature Neuroscience</a>, the UCSF study demonstrated that transplantation of medial ganglionic eminence (MGE) cells, embryonic neurons that can inhibit overactive brain signaling, was able to stop seizures in half of the epileptic mice that were treated.<div style="padding-bottom: 15px;">
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The mice also appeared less agitated and hyperactive and seemed to perform better on learning and memory tests.<div style="padding-bottom: 15px;">
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MGE cells were transplanted into a specific region of the brain known as the hippocampus, which is believed to play a part in seizures as well as learning and memory.<div style="padding-bottom: 15px;">
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<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933789/" style="color: #3366bb;" target="_blank">Previous studies</a> show that transplanted MGE cells are capable of differentiating into a variety of mature neurons, including inhibitory GABA-ergic neurons. GABA-ergic neurons are known to suppress seizures when activated and abnormal GABA-ergic activity has been linked to animal models of epilepsy.<div style="padding-bottom: 15px;">
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Cell transplants have become a recent focus in epilepsy research due to a lack of effective treatments, according to Scott C. Baraban, PhD, who led the UCSF study.<div style="padding-bottom: 15px;">
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Baraban says that current drugs are focused on treating symptoms as opposed to the cause and fail to provide therapeutic benefit in many forms of epilepsy.<div style="padding-bottom: 15px;">
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"Our results are an encouraging step toward using inhibitory neurons for cell transplantation in adults with severe forms of epilepsy," <a href="http://www.newswise.com/articles/epilepsy-cured-in-mice-using-brain-cells" style="color: #3366bb;" target="_blank">states</a> Baraban. "This procedure offers the possibility of controlling seizures and rescuing cognitive deficits in these patients."<div style="padding-bottom: 15px;">
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Still, the use of embryonic stem cells remains controversial and is significantly more invasive than conventional epilepsy treatments, which largely depend on the use of anticonvulsant medications.<div style="padding-bottom: 15px;">
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Further research is required to confirm the therapeutic value of stem cells in human epilepsy, but the UCSF team remain encouraged by their discovery.<div style="padding-bottom: 15px;">
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“This is the first report in a mouse model of adult epilepsy in which mice that already were having seizures stopped having seizures after treatment,” <a href="http://www.newswise.com/articles/epilepsy-cured-in-mice-using-brain-cells" style="color: #3366bb;" target="_blank">says</a> Baraban.<div style="padding-bottom: 15px;">
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<span><br /><br />Read more: <a href="http://www.digitaljournal.com/article/349612#ixzz2Sd9BSHuj" style="color: #003399;">http://www.digitaljournal.com/article/349612#ixzz2Sd9BSHuj</a></span></div>
Brother Bhttp://www.blogger.com/profile/08417227852143861696noreply@blogger.com0tag:blogger.com,1999:blog-5151869116317538590.post-58462617116457587202013-05-05T19:03:00.001-04:002013-05-05T19:03:56.730-04:00<div dir="ltr" style="text-align: left;" trbidi="on">
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<h1 class="sty_head_30" style="color: black; font-family: Georgia, 'Times New Roman', Times, serif; font-size: 30px; font-variant: normal; font-weight: 400; letter-spacing: -1px; line-height: 35px; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 5px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">
Stem cells may help Mumbai acid attack victim regain vision: doctors</h1>
<span class="sty_agn" style="color: black; font-weight: bold;"><a href="http://www.hindustantimes.com/Search/search.aspx?q=Priyanka%20Vora%20&op=auth" style="color: black; text-decoration: none;">Priyanka Vora </a>, Hindustan Times</span> Mumbai, May 05, 2013<div id="ctl00_ContentPlaceHolder1_HTStoryPageControl_authordiv" style="margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px;">
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First Published: 16:15 IST(5/5/2013) | Last Updated: 16:16 IST(5/5/2013)</div>
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Ophthalmologists are hoping that Preeti Rathi, 25, who lost vision in her right eye after an unknown man threw acid on her face at Bandra Terminus, may be able to regain her vision after undergoing stem cell therapy.</div>
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On Saturday morning, Rathi, who was admitted inside the burns intensive care unit at Masina Hospital at Byculla, scribbled a note pleading her ophthalmologist Dr Yasmin Bhagat to help her see with both eyes again.</div>
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“We have helped patients of acid attack to regain vision by using stem cell therapy in the past. Once she (Rathi) recovers fully we can look at harvesting stem cells from her parents’ eye and transplanting them in her right eye as the cornea is damaged by the acid,” said Dr Bhagat.</div>
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Doctors said that her condition is stable and she was put on ventilator support for a few hours to give her rest. According to doctors, Rathi’s face is fully bandaged while her eyes are stil shut. “She cannot see but her left eye is showing improvement.” added Bhagat who has treated numerous such acid attack victims in the past.</div>
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Rathi’s father Amarsingh is planning to meet officials from INHS Asvini, where Preeti was supposed join as a nurse, to postpone her joining date. “If they postpone her joining, she would be very happy,” said Amarsingh</div>
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Meanwhile, The Bandra Government Railway Police (GRP), who are probing the acid attack, have scanned the passenger list of train in which the accused was travelling. Further probe is underway.</div>
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